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PTCH1 / Patched 1
patched 1
PTCH1 / Patched 1 is a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.
| Gene Name: | patched 1 |
| Synonyms: | PTCH1, NBCCS, Patched 1, Patched homolog 1, Protein patched homolog 1, PTC1, PTCH, PTCH protein +12b, PTCH protein -10, PTCH protein -3,4,5, Patched, Patched protein homolog 1, BCNS, HPE7, Patched homolog, PTC, PTCH protein +4, PTCH11 |
| Target Sequences: | NM_000264 NP_000255.2 Q13635 |
Publications (3)
1
Ptch2 loss drives myeloproliferation and myeloproliferative neoplasm progression. Klein C, Zwick A, Kissel S, Forster CU, Pfeifer D, Follo M, Illert AL, Decker S, Benkler T, Pahl H, Oostendorp RA, Aumann K, Duyster J, Dierks C. The Journal of experimental medicine. 2016 213:273-90. (WB, ELISA; Human)
[Full Text Article]
[PubMed:26834157]
[PMC:PMC4749921]
Related Antibodies: LS-B3939.
2
Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human. Erik Kolbe, Susanne Aleithe, Christiane Rennert, Luise Spormann, Fritzi Ott, David Meierhofer, Robert Gajowski, Claus Stöpel, Stefan Hoehme, Michael Kücken, Lutz Brusch, Michael Seifert, Witigo von Schoenfels, Clemens Schafmayer, Mario Brosch, Ute Hofmann, Georg Damm, Daniel Seehofer, Jochen Hampe, Rolf Gebhardt, Madlen Matz-Soja. Cell reports. 2019 December;29:4553-4567.e7. [Full Text Article]
[PubMed:31875560]
3
Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling. Yang Gu , Yanying Wang , Luyun He , Jiahang Zhang , Xiaoxiao Zhu , Nian Liu, Jianyi Wang, Tiankun Lu, Lei He, Yong Tian, Zusen Fan. Molecular cancer. 2021 October;20:132. [Full Text Article]
[PubMed:34649567]
[PMC:PMC8515748]
Related Antibodies: LS-C114391.
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(77)
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PTCH1 / Patched 1 Goat anti-Human Polyclonal (aa1431-1442) Antibody
Dog, Horse, Bat, Human, Monkey
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$485
PTCH1 / Patched 1 Mouse anti-Human Monoclonal (OTI5C7) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$450
PTCH1 / Patched 1 Mouse anti-Human Monoclonal (aa122-436) (Carrier-free) (OTI5C7) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
PTCH1 / Patched 1 Rabbit anti-Human Polyclonal (aa1-50) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
PTCH1 / Patched 1 Rabbit anti-Human Polyclonal (aa58-107) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
PTCH1 / Patched 1 Rabbit anti-Human Polyclonal (aa58-107) (Biotin) Antibody
Zebrafish, Horse, Rat, Mouse, Dog, Guinea pig, Bovine, Human, Monkey, Gibbon
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
PTCH1 / Patched 1 Rabbit anti-Human Polyclonal (aa58-107) (FITC) Antibody
Zebrafish, Horse, Rat, Mouse, Dog, Guinea pig, Bovine, Human, Monkey, Gibbon
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
PTCH1 / Patched 1 Rabbit anti-Human Polyclonal (Ala2) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
PTCH1 / Patched 1 Goat anti-Human Polyclonal (aa266-280) Antibody
Rabbit, Mouse, Dog, Sheep, Rat, Pig, Horse, Human, Monkey
IF, Peptide-ELISA, WB
Unconjugated
100 µg/$503
PTCH1 / Patched 1 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$485
PTCH1 / Patched 1 Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody
Mouse
IHC, WB
Unconjugated
100 µl/$440; 200 µl/$468
PTCH1 / Patched 1 Mouse anti-Human Monoclonal (OTI3c2) Antibody
Human
IF, WB
Unconjugated
100 µl/$434
PTCH1 / Patched 1 Mouse anti-Human Monoclonal (aa122-436) (Carrier-free) (OTI3c2) Antibody
Human
IF, WB
Unconjugated, Carrier-free
100 µg/$511
PTCH1 / Patched 1 Rabbit anti-Human Monoclonal (Pro1307) Antibody
Human
IP, WB
Unconjugated
100 µl/$688
PTCH1 / Patched 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PTCH1 / Patched 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$394
PTCH1 / Patched 1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
PTCH1 / Patched 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
PTCH1 / Patched 1 Rabbit anti-Human Polyclonal (1-80 aa, N-terminal) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
PTCH1 / Patched 1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
PTCH1 / Patched 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
PTCH1 / Patched 1 Goat anti-Human Polyclonal (aa1271-1285) Antibody
Human, Monkey
IF, Peptide-ELISA, WB
Unconjugated
100 µg/$503
PTCH1 / Patched 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
PTCH1 / Patched 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
PTCH1 / Patched 1 Mouse anti-Human Monoclonal (1G2) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
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