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RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA.
Gene Name: | polypyrimidine tract binding protein 2 |
Synonyms: | PTBP2, BrPTB, NPTB5, NPTB6, NPTB8, PTB, PTB-like protein, Splicing regulator, NPTB, PTBLP, NPTB7 |
Target Sequences: | NM_021190 NP_067013.1 Q9UKA9 |
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