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PTAR2 / FNTA

farnesyltransferase, CAAX box, alpha

Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation.

Gene Name: farnesyltransferase, CAAX box, alpha
Synonyms: FNTA, FPTA, FTase-alpha, GGTase-I-alpha, PTAR2, PGGT1A
Target Sequences: NM_002027 NP_002018.1 P49354

Publications (1)

1
OKlahoma Nitrone-007: novel treatment for diffuse intrinsic pontine glioma. Lincy Thomas, Nataliya Smith, Debra Saunders, Michelle Zalles, Rafal Gulej, Megan Lerner, Kar-Ming Fung, Angel M Carcaboso, Rheal A Towner. Journal of translational medicine. 2020 November;18:424. [Full Text Article] [PubMed:33168005] [PMC:PMC7654606]

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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
PTAR2 / FNTA (5)
No (5)
GST (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (4)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (1)
PTAR2 / FNTA Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
44.2 kDa
100 µg/$494
PTAR2 / FNTA Protein - 12.5% SDS-PAGE of human FNTA stained with Coomassie Blue
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Wheat Germ Extract
GST
67.32 kDa
10 µg/$479; 25 µg/$670
PTAR2 / FNTA Protein - Recombinant Farnesyltransferase Alpha By SDS-PAGE
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E. coli
His-T7
43.7 kDa
10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
PTAR2 / FNTA Protein - Purified recombinant protein FNTA was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
44.2 kDa
20 µg/$1,107
PTAR2 / FNTA Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
44.2 kDa
20 µg/$150
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).