PSME4 / PA200

proteasome (prosome, macropain) activator subunit 4

Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

PSME4 / PA200 (3)

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No (3)

Tag

Myc-DDK (Flag) (3)

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Human (2)

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293T Cells (1)

HEK 293 Cells (2)

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PSME4 / PA200 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G113832

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

211.2 kDa

Price:

100 µg/$710

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Human PSME4 / PA200 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67870

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

211.2 kDa

Price:

20 µg/$1,107

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Human PSME4 / PA200 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80890

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

211.2 kDa

Price:

20 µg/$215

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