PSME2

proteasome (prosome, macropain) activator subunit 2 (PA28 beta)

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

PSME2 (7)

Publications

No (7)

Tag

GST (2)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (6)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human PSME2 Protein (Recombinant GST, N-terminus) (aa1-90) - LS-G59798

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PSME2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67878

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.2 kDa

Price:

20 µg/$1,107

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Human PSME2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80910

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.2 kDa

Price:

20 µg/$150

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Human PSME2 Protein (Recombinant GST) (Full Length) - LS-G22093

Source:

E. coli

Tag:

GST

Molecular Weight:

54.7 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human PSME2 Protein (Recombinant GST) (Full Length) - LS-G30007

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

52.03 kDa

Price:

10 µg/$479; 25 µg/$670

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PSME2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99884

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.2 kDa

Price:

100 µg/$494

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Human PSME2 Protein (Recombinant His) - LS-G1507

Source:

E. coli

Tag:

His

Price:

50 µg/$381; 250 µg/$838; 10 µg/$266; 20 µg/$306; 100 µg/$492; 500 µg/$1,231

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