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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PSME2

proteasome (prosome, macropain) activator subunit 2 (PA28 beta)

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13.

Gene Name: proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
Synonyms: PSME2, REGbeta, PA28B, Proteasome activator 28-beta, MCP activator, 31-kD subunit, PA28beta, REG-beta
Target Sequences: NM_002818 NP_002809.2 Q9UL46

Filtered By: None
Target
PSME2 (35)
Reactivity
Human (35)
Mouse (22)
Rat (8)
Bat (9)
Bovine (5)
Chimpanzee (6)
Dog (8)
Gibbon (6)
Guinea pig (4)
Hamster (9)
Horse (5)
Monkey (9)
Pig (9)
Rabbit (4)
Zebrafish (8)
Application
IHC (19)
IHC-P (5)
WB (34)
Flo (8)
ELISA (19)
IP (3)
Peptide-ELISA (1)
Host
rabbit (32)
mouse (2)
goat (1)
Isotype
IgG (18)
IgG2a,k (1)
Clonality
monoclonal mc (2)
polyclonal pc (33)
Clone
1G4 (1)
Format
AP Conjugated (1)
APC Conjugated (1)
Biotin Conjugated (5)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (1)
Unconjugated (17)
Epitope
aa61-91 (8)
C-Terminus (4)
aa143-192 (4)
aa210-239 (1)
aa223-236 (1)
Publications
No (35)
Showing 1-25 of 35 results

PSME2 Antibody (aa223-236) IHC-plus™ LS-B9499
Goat Polyclonal to Human PSME2
Mouse, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IHC IHC-P Peptide-ELISA WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-PSME2 antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Antibody (0.5 ug/ml) staining of Human Spleen lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Anti-PSME2 antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Antibody (0.5 ug/ml) staining of Human Spleen lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

PSME2 Antibody (clone 1G4) LS-C133069
Mouse Monoclonal [clone 1G4] (IgG2a,k) to Human PSME2
Human
ELISA IHC IHC-P IP WB
Unconjugated
100µg 0.43mg/ml  $355.00
Immunoperoxidase of monoclonal antibody to PSME2 on formalin-fixed paraffin-embedded human stomach carcinoma. [antibody concentration 6 ug/ml].
PSME2 monoclonal antibody (M02), clone 1G4 Western blot of PSME2 expression in MCF-7.
Immunoperoxidase of monoclonal antibody to PSME2 on formalin-fixed paraffin-embedded human stomach carcinoma. [antibody concentration 6 ug/ml].
PSME2 monoclonal antibody (M02), clone 1G4 Western blot of PSME2 expression in MCF-7.

PSME2 Antibody (aa61-91) LS-C162250
Rabbit Polyclonal to Human PSME2
Mouse, Human
Flo IHC IHC-P WB
Unconjugated
400µl  $305.00
Formalin-fixed and paraffin-embedded mouse hepatocarcinoma reacted with PSME2 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Western blot of lysates from MCF-7, HepG2 cell line (from left to right), using PSME2 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.
Formalin-fixed and paraffin-embedded mouse hepatocarcinoma reacted with PSME2 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Western blot of lysates from MCF-7, HepG2 cell line (from left to right), using PSME2 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.

PSME2 Antibody (aa61-91) LS-C328332
Rabbit Polyclonal (IgG) to Human PSME2
Mouse, Human
ELISA Flo IHC WB
Unconjugated
200µl 0.25mg/ml  $530.00

PSME2 Antibody (aa61-91, HRP) LS-C549011
Rabbit Polyclonal (IgG) to Human PSME2
Mouse, Human
ELISA IHC WB
HRP Conjugated
200µl  $680.00

PSME2 Antibody (aa61-91, Biotin) LS-C528920
Rabbit Polyclonal (IgG) to Human PSME2
Mouse, Human
ELISA Flo IHC WB
Biotin Conjugated
200µl  $680.00

PSME2 Antibody (aa61-91, FITC) LS-C538866
Rabbit Polyclonal (IgG) to Human PSME2
Mouse, Human
Flo IHC WB
FITC Conjugated
200µl  $680.00

PSME2 Antibody (aa61-91, APC) LS-C281296
Rabbit Polyclonal (IgG) to Human PSME2
Mouse, Human
ELISA Flo IHC WB
APC Conjugated
200µl  $680.00

PSME2 Antibody (aa61-91, PE) LS-C281298
Rabbit Polyclonal (IgG) to Human PSME2
Mouse, Human
ELISA Flo IHC WB
PE Conjugated
200µl  $680.00

PSME2 Antibody (aa61-91, AP) LS-C281295
Rabbit Polyclonal (IgG) to Human PSME2
Mouse, Human
ELISA Flo IHC WB
AP Conjugated
200µl  $680.00

PSME2 Antibody (aa210-239) LS-C162249
Rabbit Polyclonal to Human PSME2
Mouse, Human
Flo IHC IHC-P WB
Unconjugated
400µl  $305.00
Formalin-fixed and paraffin-embedded mouse hepatocarcinoma reacted with PSME2 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Western blot of lysate from HepG2 cell line, using PSME2 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.
Formalin-fixed and paraffin-embedded mouse hepatocarcinoma reacted with PSME2 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Western blot of lysate from HepG2 cell line, using PSME2 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.

PSME2 Antibody LS-C751880
Rabbit Polyclonal (IgG) to Human PSME2
Human
ELISA IHC WB
Unconjugated
100µg  $335.00

PSME2 Antibody LS-C484719
Mouse Monoclonal to Human PSME2
Human
ELISA IP WB
Unconjugated
50µl  $255.00; 100µl  $305.00; 200µl  $355.00

PSME2 Antibody LS-C482468
Rabbit Polyclonal to Human PSME2
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
50µl 1mg/ml  $255.00; 100µl 1mg/ml  $295.00; 200µl 1mg/ml  $375.00
Immunohistochemical analysis of PA28 beta staining in human gastric cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Western blot analysis of PA28 beta expression in SW480 (A); HepG2 (B); mouse liver (C); mouse lung (D) whole cell lysates.
Immunohistochemical analysis of PA28 beta staining in human gastric cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Western blot analysis of PA28 beta expression in SW480 (A); HepG2 (B); mouse liver (C); mouse lung (D) whole cell lysates.

PSME2 Antibody LS-C211006
Rabbit Polyclonal (IgG) to Human PSME2
Human
ELISA WB
Unconjugated
50µg  $285.00; 100µg  $385.00

PSME2 Antibody (HRP) LS-C211007
Rabbit Polyclonal (IgG) to Human PSME2
Human
ELISA IHC WB
HRP Conjugated
50µg  $285.00; 100µg  $385.00

PSME2 Antibody (Biotin) LS-C211009
Rabbit Polyclonal (IgG) to Human PSME2
Human
ELISA IHC WB
Biotin Conjugated
50µg  $285.00; 100µg  $385.00

PSME2 Antibody (FITC) LS-C211008
Rabbit Polyclonal (IgG) to Human PSME2
Human
ELISA IHC WB
FITC Conjugated
50µg  $285.00; 100µg  $385.00

PSME2 Antibody LS-C484720
Rabbit Polyclonal to Human PSME2
Human
ELISA IP WB
Unconjugated
50µl  $255.00; 100µl  $305.00; 200µl  $355.00

PSME2 Antibody LS-C341319
Rabbit Polyclonal to Human PSME2
Mouse, Rat, Human
IHC WB
Unconjugated
100µl 1mg/ml  $385.00

PSME2 Antibody LS-C748672
Rabbit Polyclonal (IgG) to Human PSME2
Mouse, Human
IHC WB
Unconjugated
50µl  $235.00
Immunohistochemistry of paraffin-embedded human gastric cancer using PSME2 antibody at dilution of 1:100 (40x lens).
Western blot analysis of extracts of various cell lines, using PSME2 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.
Immunohistochemistry of paraffin-embedded human gastric cancer using PSME2 antibody at dilution of 1:100 (40x lens).
Western blot analysis of extracts of various cell lines, using PSME2 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.

PSME2 Antibody LS-C334141
Rabbit Polyclonal (IgG) to Human PSME2
Mouse, Rat, Human
IHC WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Immunohistochemistry of paraffin-embedded human gastric cancer tissue.
Western blot analysis of extracts of various cell lines.
Immunohistochemistry of paraffin-embedded human gastric cancer tissue.
Western blot analysis of extracts of various cell lines.

PSME2 Antibody LS-C190018
Rabbit Polyclonal (IgG) to Human PSME2
Human
ELISA WB
Unconjugated
100µg  $455.00

PSME2 Antibody (HRP) LS-C183267
Rabbit Polyclonal (IgG) to Human PSME2
Human
ELISA WB
HRP Conjugated
100µg  $455.00

PSME2 Antibody (Biotin) LS-C183269
Rabbit Polyclonal (IgG) to Human PSME2
Human
ELISA WB
Biotin Conjugated
100µg  $455.00
Showing 1-25 of 35 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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