PSME1

proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Alternative splicing results in multiple transcript variants.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

PSME1 (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (3)

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Human PSME1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66064

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.5 kDa

Price:

20 µg/$1,107

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Human PSME1 Protein (Recombinant GST, N-terminus) (aa1-249) - LS-G56472

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human PSME1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76841

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.5 kDa

Price:

20 µg/$150

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Human PSME1 Protein (Recombinant GST) (Full Length) - LS-G30005

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

55.1 kDa

Price:

10 µg/$479; 25 µg/$670

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PSME1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100770

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

28.5 kDa

Price:

100 µg/$494

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Human PSME1 Protein (Recombinant His) - LS-G971

Source:

E. coli

Tag:

His

Price:

50 µg/$361; 250 µg/$739; 10 µg/$261

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