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Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.
|Gene Name:||proteasome (prosome, macropain) 26S subunit, non-ATPase, 14|
|Synonyms:||PSMD14, PAD1, POH1, RPN11|
|Target Sequences:||NM_005805 NP_005796.1 O00487|
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