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PSMD10 / Gankyrin
proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pahway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export.
| Gene Name: | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 |
| Family/Subfamily: | Protease Non Catalytic , not assigned-Protease Non Catalytic |
| Synonyms: | PSMD10, 26s proteasome subunit 10, Ankyrin repeat protein, DJ889N15.2, Gankyrin, p28, p28(GANK) |
| Target Sequences: | NM_002814 NP_002805.1 O75832 |
Publications (1)
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