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PSMC3

proteasome (prosome, macropain) 26S subunit, ATPase, 3

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.

Gene Name: proteasome (prosome, macropain) 26S subunit, ATPase, 3
Family/Subfamily: ATPase , not assigned-ATPase
Synonyms: PSMC3, Proteasome subunit P50, TBP1, TBP-1, Rpt5, Tat-binding protein 1
Target Sequences: NM_002804 NP_002795.2 P17980

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Products
Proteins (7)
Over-Expression Lysate (2)
Recombinant (5)
PSMC3 (7)
No (7)
GST (1)
GST, N-terminus (1)
His (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (6)
293T Cells (1)
E. coli (2)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
Low endotoxin level (1)
PSMC3 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
PSMC3 Protein - Purified recombinant protein PSMC3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
49 kDa
20 µg/$1,107
PSMC3 Protein - Recombinant Proteasome 26S Subunit, ATPase 3 By SDS-PAGE
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E. coli
His-T7
52.9 kDa
10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
PSMC3 Protein - 12.5% SDS-PAGE of human PSMC3 stained with Coomassie Blue
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Wheat Germ Extract
GST
75.6 kDa
10 µg/$479; 25 µg/$670
PSMC3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
49 kDa
100 µg/$494
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E. coli
151 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
16.72 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
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293T Cells
Myc-DDK (Flag)
49 kDa
20 µg/$150
Viewing 1-7 of 7 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).