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PSMC3
proteasome (prosome, macropain) 26S subunit, ATPase, 3
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.
| Gene Name: | proteasome (prosome, macropain) 26S subunit, ATPase, 3 |
| Family/Subfamily: | ATPase , not assigned-ATPase |
| Synonyms: | PSMC3, Proteasome subunit P50, TBP1, TBP-1, Rpt5, Tat-binding protein 1 |
| Target Sequences: | NM_002804 NP_002795.2 P17980 |
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