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PSMB5

proteasome (prosome, macropain) subunit, beta type, 5

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit). Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: proteasome (prosome, macropain) subunit, beta type, 5
Family/Subfamily: Protease , Threonine T1
Synonyms: PSMB5, Proteasome chain 6, Proteasome subunit MB1, Proteasome subunit X, Proteasome catalytic subunit 3, Macropain epsilon chain, MB1, LMPX, Proteasome beta 5 subunit, Proteasome epsilon chain, Proteasome subunit beta type-5
Target Sequences: NM_002797 NP_002788.1 P28074

Publications (2)

1
Uncommon functional properties of the first piscine 26S proteasome from the Antarctic notothenioid Trematomus bernacchii. Gogliettino M, Balestrieri M, Riccio A, Facchiano A, Fusco C, Palazzo VC, Rossi M, Cocca E, Palmieri G. Bioscience reports. 2016 36: (WB; Human) [Full Text Article] [PubMed:26933238] [PMC:PMC4832319] Related Antibodies: LS-C111925.
2
Unusual Antioxidant Properties of 26S Proteasome Isolated from Cold-Adapted Organisms. Gogliettino M, Cocca E, Fusco C, Agrillo B, Riccio A, Balestrieri M, Facchiano A, Pepe A, Palmieri G. International journal of molecular sciences. 2017 18: (WB; Human) [Full Text Article] [PubMed:28757562] [PMC:PMC5577997] Related Antibodies: LS-C111925.

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Proteins (8)
Over-Expression Lysate (4)
Recombinant (4)
PSMB5 (8)
No (8)
GST (1)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (5)
Human (6)
293T Cells (2)
E. coli (1)
HEK 293 Cells (3)
Wheat Germ Extract (2)
Purified (2)
PSMB5 Protein - Purified recombinant protein PSMB5 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
28.3 kDa
20 µg/$1,107
PSMB5 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
PSMB5 Protein - 12.5% SDS-PAGE of human PSMB5 stained with Coomassie Blue
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Wheat Germ Extract
GST
54.45 kDa
10 µg/$479; 25 µg/$670
PSMB5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
28.3 kDa
100 µg/$494
PSMB5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
28.48 kDa
100 µg/$494
PSMB5 Protein
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E. coli
His
50 µg/$411; 250 µg/$985; 10 µg/$276
PSMB5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
28.48 kDa
20 µg/$150
PSMB5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
28.3 kDa
20 µg/$150
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).