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PSMB10

proteasome (prosome, macropain) subunit, beta type, 10

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome.

Gene Name: proteasome (prosome, macropain) subunit, beta type, 10
Family/Subfamily: Protease Non Catalytic , Threonine T1
Synonyms: PSMB10, Beta2i, Low molecular mass protein 10, MECL1, Proteasome component mecl-1, Proteasome subunit beta-2i, Proteasome subunit beta 7i, Macropain subunit MECl-1, Proteasome MECl-1, LMP10, Proteasome subunit MECL1
Target Sequences: BC017198 NP_002792.1 P40306

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PSMB10 ELISA Kit
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0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
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1 Plate/$834
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).