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The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene Name: | proteasome (prosome, macropain) subunit, alpha type, 4 |
Family/Subfamily: | Protease Non Catalytic , Threonine T1 |
Synonyms: | PSMA4, HC9, HsT17706, Proteasome subunit L, Macropain subunit C9, PSC9, Proteasome component C9, Proteasome subunit HC9 |
Target Sequences: | NM_002789 NP_002780.1 P25789 |
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