PSEN1 / Presenilin 1

presenilin 1

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

PSEN1 / Presenilin 1 (5)

Publications

No (5)

Tag

6His, N-terminus (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human PSEN1 / Presenilin 1 Protein (Recombinant 6His, N-terminus) (Thr2-Phe82) - LS-G26493

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

22.2 kDa

Price:

10 µg/$265; 50 µg/$315; 100 µg/$365

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Human PSEN1 / Presenilin 1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66639

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.5 kDa

Price:

20 µg/$1,107

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Human PSEN1 / Presenilin 1 Protein (Recombinant GST, N-terminus) (aa280-379) - LS-G59779

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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PSEN1 / Presenilin 1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123442

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.5 kDa

Price:

100 µg/$494

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Human PSEN1 / Presenilin 1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78168

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.5 kDa

Price:

20 µg/$150

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