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Unfortunately, the antibody (ID:3793) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



PSEN1 / Presenilin 1

presenilin 1

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.

Gene Name: presenilin 1
Family/Subfamily: protease , Aspartic A22A
Synonyms: PSEN1, AD3, Alzheimer disease 3, FAD, Protein S182, PS1, S182, PS-1, PSNL1, Presenilin 1, Presenilin-1
Target Sequences: NM_000021 NP_000012.1 P49768

Filtered By: None
Target
psen1-presenilin-1 (72)
Reactivity
Human (72)
Mouse (38)
Rat (24)
Bat (4)
Bovine (4)
Chimpanzee (6)
Dog (4)
Gibbon (6)
Guinea pig (8)
Hamster (8)
Horse (4)
Monkey (14)
Orangutan (6)
Pig (8)
Primate (1)
Xenopus (1)
Application
IHC (47)
IHC-Fr (5)
IHC-P (17)
WB (61)
Flo (2)
ELISA (36)
ICC (3)
IF (2)
IP (7)
Peptide-ELISA (3)
Host
rabbit (60)
mouse (4)
goat (4)
chicken (1)
rat (3)
Isotype
IgG (49)
IgG1 (5)
IgY (1)
Clonality
monoclonal mc (7)
polyclonal pc (65)
Clone
17C2 (1)
24-4B5 (1)
34-4C3 (1)
Format
AP Conjugated (3)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (6)
CF Conjugated (1)
FITC Conjugated (6)
HRP Conjugated (6)
PE Conjugated (3)
Unconjugated (45)
Epitope
N-Terminus (8)
aa330-359 (8)
aa107-156 (4)
aa300-349 (4)
aa431-467 (3)
aa14-33 (2)
pSer357 (2)
C-Terminus (1)
Ser28 (1)
Val293 (1)
aa1-160 (1)
aa1-50 (1)
aa1-79 (1)
aa10-90 (1)
aa21-80 (1)
aa263-378 (1)
aa275-367 (1)
aa300-380 (1)
aa313-334 (1)
aa323-372 (1)
aa345-359 (1)
Publications
No (72)
Showing 1-25 out of 72 results
PSEN1 / Presenilin 1 Antibody (aa107-156) IHC-plus™ LS-B6832
Anti-PSEN1 / Presenilin 1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6832 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
PSEN1 / Presenilin 1 antibody LS-B6832 Western blot of OVCAR-3 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

Rabbit Polyclonal to Human PSEN1 / Presenilin 1
Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Bat, Human, Monkey
IHC IHC-P WB
Unconjugated
PSEN1 / Presenilin 1 Antibody LS-C26137

Rabbit Polyclonal (IgG) to Human PSEN1 / Presenilin 1
Xenopus, Rat, Mouse, Human
ELISA WB
Unconjugated
PSEN1 / Presenilin 1 Antibody (aa330-359) LS-C100478
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Confocal immunofluorescence of Presenilin 1 (PSEN1) Antibody with MDA-MB435 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

Rabbit Polyclonal to Human PSEN1 / Presenilin 1
Mouse, Human
Flo IF IHC IHC-P WB
Unconjugated
PSEN1 / Presenilin 1 Antibody LS-C330776
Western blot analysis of extracts of 293 cells.

Rabbit Polyclonal (IgG) to Human PSEN1 / Presenilin 1
Mouse, Human
Flo IF IHC WB
Unconjugated
PSEN1 / Presenilin 1 Antibody (aa263-378) LS-C26120

Mouse Monoclonal (IgG1) to Human PSEN1 / Presenilin 1
Mouse, Rat, Human
ELISA ICC IHC IHC-P IP WB
Unconjugated
PSEN1 / Presenilin 1 Antibody (aa300-349) IHC-plus™ LS-B6952
Anti-PSEN1 / Presenilin 1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6952 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
PSEN1 / Presenilin 1 antibody LS-B6952 Western blot of Fetal Brain lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

Rabbit Polyclonal to Human PSEN1 / Presenilin 1
Mouse, Guinea pig, Bovine, Pig, Horse, Human, Monkey
IHC IHC-P WB
Unconjugated
PSEN1 / Presenilin 1 Antibody (C-Terminus) IHC-plus™ LS-B1390
Anti-PSEN1 / Presenilin 1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1390 concentration 5 ug/ml.
Immunofluorescence of Presenilin1 in Human Brain cells with Presenilin1 antibody at 20 ug/ml.

Rabbit Polyclonal (IgG) to Human PSEN1 / Presenilin 1
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
PSEN1 / Presenilin 1 Antibody (phospho-Ser357) LS-C199498
IHC of paraffin-embedded human brain, using PSEN1 (Phospho-Ser357) Antibody. The sample on the right was incubated with synthetic peptide.

Rabbit Polyclonal (IgG) to Human PSEN1 / Presenilin 1
Mouse, Rat, Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
PSEN1 / Presenilin 1 Antibody (aa1-50) LS-C118561
IHC of paraffin-embedded human brain tissue, using Presenilin 1 Antibody. The picture on the right is treated with the synthesized peptide.

Rabbit Polyclonal (IgG) to Human PSEN1 / Presenilin 1
Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
PSEN1 / Presenilin 1 Antibody (aa323-372) LS-C199497
IHC of paraffin-embedded human brain tissue, using PSEN1 Antibody. The sample on the right was incubated with synthetic peptide.

Rabbit Polyclonal (IgG) to Human PSEN1 / Presenilin 1
Mouse, Rat, Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
PSEN1 / Presenilin 1 Antibody (N-Terminus) LS-C26136

Rat Monoclonal (IgG) to Human PSEN1 / Presenilin 1
Human
ELISA IHC IP WB
Unconjugated
PSEN1 / Presenilin 1 Antibody (N-Terminus) LS-C48030

Rabbit Polyclonal to Human PSEN1 / Presenilin 1
Human
ELISA IHC IP WB
Unconjugated
PSEN1 / Presenilin 1 Antibody (N-Terminus) LS-C26124

Goat Polyclonal (IgG) to Human PSEN1 / Presenilin 1
Human
ELISA IHC IHC-Fr IHC-P WB
Unconjugated
PSEN1 / Presenilin 1 Antibody (aa1-160) LS-C376425
Immunohistochemistry of paraffin-embedded human epityphlon using antibody at 1:100 dilution.
Western blot. All lanes: Presenilin-1 antibody at 2 ug/ml+HeLa whole cell lysate. Secondary antibody: Goat polyclonal to rabbit at 1:10000 dilution. Predicted band size: 53 kDa. Observed band size: 53 kDa.

Rabbit Polyclonal (IgG) to Human PSEN1 / Presenilin 1
Human
ELISA IHC IHC-P WB
Unconjugated
PSEN1 / Presenilin 1 Antibody LS-C26121

Rabbit Polyclonal (IgG) to Human PSEN1 / Presenilin 1
Human, Monkey
IHC IHC-Fr IP WB
Unconjugated
PSEN1 / Presenilin 1 Antibody LS-C679213
Immunohistochemistry of paraffin-embedded human brain tissue at dilution 1:100
Paraffin-embedding Immunohistochemistry using human liver tissue at dilution 1:100

Rabbit Polyclonal (IgG) to Human PSEN1 / Presenilin 1
Human
ELISA IHC WB
Unconjugated
PSEN1 / Presenilin 1 Antibody (aa313-334) LS-C26130

Mouse Monoclonal (IgG1) to Human PSEN1 / Presenilin 1
Human
ELISA ICC WB
Unconjugated
PSEN1 / Presenilin 1 Antibody (aa10-90) LS-C385649

Rabbit Polyclonal (IgG) to Human PSEN1 / Presenilin 1
Human
ELISA IHC WB
Unconjugated
PSEN1 / Presenilin 1 Antibody (phospho-Ser357) LS-C381430

Rabbit Polyclonal (IgG) to Human PSEN1 / Presenilin 1
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
PSEN1 / Presenilin 1 Antibody (aa330-359) LS-C328300

Rabbit Polyclonal (IgG) to Human PSEN1 / Presenilin 1
Mouse, Human
ELISA IHC WB
Unconjugated
PSEN1 / Presenilin 1 Antibody (aa330-359, FITC) LS-C281154

Rabbit Polyclonal (IgG) to Human PSEN1 / Presenilin 1
Mouse, Human
ELISA IHC WB
FITC Conjugated
PSEN1 / Presenilin 1 Antibody (aa330-359, APC) LS-C281151

Rabbit Polyclonal (IgG) to Human PSEN1 / Presenilin 1
Mouse, Human
ELISA IHC WB
APC Conjugated
PSEN1 / Presenilin 1 Antibody (aa300-380) LS-C385634
Western blot of Presenilin 1 antibody

Rabbit Polyclonal (IgG) to Human PSEN1 / Presenilin 1
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
PSEN1 / Presenilin 1 Antibody (aa275-367) LS-C26122

Rabbit Polyclonal (IgG) to Human PSEN1 / Presenilin 1
Mouse, Hamster, Human, Monkey
ICC IP WB
Unconjugated
PSEN1 / Presenilin 1 Antibody (N-Terminus, clone 17C2) LS-C193603

Mouse Monoclonal [clone 17C2] (IgG1) to Human PSEN1 / Presenilin 1
Human
IHC WB
Unconjugated

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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