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PRTN3 / Myeloblastin

proteinase 3

Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.

Gene Name:	proteinase 3
Family/Subfamily:	Protease , Serine S1
Synonyms:	PRTN3, ACPA, Azurophil granule protein 7, C-ANCA antigen, CANCA, C-ANCA, AGP7, Leukocyte proteinase 3, MBN, Myeloblastin, NP-4, Neutrophil proteinase 4, NP4, p29, PR-3, Proteinase 3, MBT, Wegener autoantigen, PR3, Serine proteinase, neutrophil
Target Sequences:	NM_002777 NP_002768.3 P24158

Publications (3)

IL-1 and IL-36 are dominant cytokines in generalized pustular psoriasis. Johnston A, Xing X, Wolterink L, Barnes DH, Yin Z, Reingold L, Kahlenberg JM, Harms PW, Gudjonsson JE. The Journal of allergy and clinical immunology. 2017 July;140:109-120. [Full Text Article] [PubMed:28043870] [PMC:PMC5494022]

Membrane-Associated Proteinase 3 on Granulocytes and Acute Myeloid Leukemia Inhibits T Cell Proliferation. Yang TH, St John LS, Garber HR, Kerros C, Ruisaard KE, Clise-Dwyer K, Alatrash G, Ma Q, Molldrem JJ. Journal of immunology (Baltimore, Md. : 1950). 2018 September;201:1389-1399. [Full Text Article] [PubMed:30021768] [PMC:PMC6099529] Related Antibodies: LS-C38480.

Inflammatory Proteins HMGA2 and PRTN3 as Drivers of Vulvar Squamous Cell Carcinoma Progression. Agnieszka Fatalska, Natalia Rusetska, Elwira Bakula-Zalewska, Artur Kowalik, Sebastian Zieba, Agnieszka Wroblewska, Kamil Zalewski, Krzysztof Goryca, Dominik Domanski, Magdalena Kowalewska. Cancers. 2020 December;13: [Full Text Article] [PubMed:33374674] [PMC:PMC7793473]

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