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PRSS2 / Trypsin 2

protease, serine, 2 (trypsin 2)

PRSS2 / Trypsin 2 belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.

Gene Name: protease, serine, 2 (trypsin 2)
Family/Subfamily: Protease , Serine S1
Synonyms: PRSS2, Anionic trypsinogen, Protease serine 2, Serine protease 2, Tesp4, TRY2, TRYP2, Trypsinogen 2, TRY8, Trypsin II, Trypsin-2, Trypsinogen II, Trypsin 2
Target Sequences: NM_002770 NP_002761.1 P07478

Publications (1)

1
Identification of trypsin-degrading commensals in the large intestine. Youxian Li , Eiichiro Watanabe , Yusuke Kawashima , Damian R Plichta, Zhujun Wang, Makoto Ujike, Qi Yan Ang, Runrun Wu, Munehiro Furuichi, Kozue Takeshita, Koji Yoshida, Keita Nishiyama, Sean M Kearney, Wataru Suda, Masahira Hattori, Satoshi Sasajima, Takahiro Matsunaga, Xiaoxi Zhang, Kazuto Watanabe, Jun Fujishiro, Jason M Norman, Bernat Olle, Shutoku Matsuyama, Ho Namkoong, Yoshifumi Uwamino, Makoto Ishii, Koichi Fukunaga, Naoki Hasegawa, Osamu Ohara, Ramnik J Xavier, Koji Atarashi, Kenya Hond. Nature. 2022 September;609:582-589. [Full Text Article] [PubMed:36071157] [PMC:PMC9477747] Related Antibodies: LS-B15726, LS-C296077.

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Antibodies (38)
Primary (38)
PRSS2 / Trypsin 2 (38)
Human (26)
Mouse (12)
Rat (2)
Dog (4)
Pig (8)
IHC (10)
IHC-P (3)
WB (29)
ELISA (18)
IP (1)
rabbit (37)
mouse (1)
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IHCPlus (2)
IgG (16)
IgG1 (1)
monoclonal mc (1)
polyclonal pc (37)
APC (2)
APC Conjugated (3)
Azide-free (1)
Biotin Conjugated (5)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (3)
Unconjugated (13)
aa24-241 (8)
aa29-240 (8)
aa80-108 (6)
aa16-247 (1)
aa79-108 (1)
No (36)
Yes (2)
PRSS2 / Trypsin 2 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PRSS2 / Trypsin 2 Rabbit anti-Human Polyclonal (aa79-108) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$485
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PRSS2 / Trypsin 2 Rabbit anti-Human Polyclonal (aa80-108) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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PRSS2 / Trypsin 2 Rabbit anti-Human Polyclonal (aa80-108) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
Select
PRSS2 / Trypsin 2 Rabbit anti-Human Polyclonal (aa80-108) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
Select
PRSS2 / Trypsin 2 Rabbit anti-Human Polyclonal (aa80-108) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
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PRSS2 / Trypsin 2 Rabbit anti-Human Polyclonal (aa80-108) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
PRSS2 / Trypsin 2 Antibody - Western blot of recombinant PRSS2 / Trypsin 2.
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PRSS2 / Trypsin 2 Rabbit anti-Mouse Polyclonal (aa29-240) Antibody
Mouse
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
PRSS2 / Trypsin 2 Antibody - Western blot of recombinant PRSS2 / Trypsin 2.
Select
PRSS2 / Trypsin 2 Rabbit anti-Mouse Polyclonal (aa29-240) (HRP) Antibody
Mouse
WB
HRP Conjugated
100 µl/$335; 200 µl/$389; 500 µl/$566; 1 ml/$685; 2 ml/$922; 5 ml/$1,557
PRSS2 / Trypsin 2 Antibody - Western blot of recombinant PRSS2 / Trypsin 2.
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PRSS2 / Trypsin 2 Rabbit anti-Mouse Polyclonal (aa29-240) (Biotin) Antibody
Mouse
WB
Biotin Conjugated
100 µl/$316; 200 µl/$361; 500 µl/$511; 1 ml/$587; 2 ml/$809; 5 ml/$1,317
PRSS2 / Trypsin 2 Antibody - Western blot of recombinant PRSS2 / Trypsin 2.
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PRSS2 / Trypsin 2 Rabbit anti-Mouse Polyclonal (aa29-240) (FITC) Antibody
Mouse
WB
FITC Conjugated
100 µl/$345; 200 µl/$402; 500 µl/$594; 1 ml/$737; 2 ml/$976; 5 ml/$1,676
PRSS2 / Trypsin 2 Antibody - Western blot of recombinant PRSS2 / Trypsin 2.
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PRSS2 / Trypsin 2 Rabbit anti-Mouse Polyclonal (aa29-240) (APC, Cy7) Antibody
Mouse
WB
APC, Cy7 Conjugated
100 µl/$497; 200 µl/$632; 500 µl/$1,132; 1 ml/$1,369; 2 ml/$1,916; 5 ml/$3,592
PRSS2 / Trypsin 2 Antibody - Western blot of recombinant PRSS2 / Trypsin 2.
Select
PRSS2 / Trypsin 2 Rabbit anti-Mouse Polyclonal (aa29-240) (APC) Antibody
Mouse
WB
APC Conjugated
100 µl/$402; 200 µl/$484; 500 µl/$834; 1 ml/$991; 2 ml/$1,277; 5 ml/$2,395
PRSS2 / Trypsin 2 Antibody - Western blot of recombinant PRSS2 / Trypsin 2.
Select
PRSS2 / Trypsin 2 Rabbit anti-Mouse Polyclonal (aa29-240) (Cy3) Antibody
Mouse
WB
Cy3 Conjugated
100 µl/$402; 200 µl/$484; 500 µl/$834; 1 ml/$991; 2 ml/$1,277; 5 ml/$2,395
PRSS2 / Trypsin 2 Antibody - Western blot of recombinant PRSS2 / Trypsin 2.
Select
PRSS2 / Trypsin 2 Rabbit anti-Mouse Polyclonal (aa29-240) (PE) Antibody
Mouse
WB
PE Conjugated
100 µl/$402; 200 µl/$484; 500 µl/$834; 1 ml/$991; 2 ml/$1,277; 5 ml/$2,395
PRSS2 / Trypsin 2 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE), at a concentration of 10 ug/ml.
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PRSS2 / Trypsin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
PRSS2 / Trypsin 2 Antibody - Western blot analysis of extracts of mouse tissues.
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PRSS2 / Trypsin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
PRSS2 / Trypsin 2 Antibody - PRSS2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human pancreas tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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PRSS2 / Trypsin 2 Rabbit anti-Human Polyclonal (aa80-108) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
PRSS2 / Trypsin 2 Antibody - Western blot of PRSS2 / Trypsin 2 antibody.
Select
PRSS2 / Trypsin 2 Rabbit anti-Human Polyclonal (aa24-241) Antibody
Pig, Human
WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182
Select
PRSS2 / Trypsin 2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
Select
PRSS2 / Trypsin 2 Mouse anti-Human Monoclonal (aa16-247) Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$896
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PRSS2 / Trypsin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
Select
PRSS2 / Trypsin 2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
100 µl/$412
PRSS2 / Trypsin 2 Antibody - Western blot analysis of Trypsin 2 expression in HT102 (A), SW620 (B), CT26 (C), PC12 (D) whole cell lysates.
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PRSS2 / Trypsin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
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PRSS2 / Trypsin 2 Rabbit anti-Dog Polyclonal Antibody
Dog
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
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PRSS2 / Trypsin 2 Rabbit anti-Human Polyclonal Antibody
Human
Unconjugated
100 µl/$357
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).