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Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP By similarity. Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation.
Gene Name: | TP53 regulating kinase |
Family/Subfamily: | Protein Kinase , Bud32 |
Synonyms: | TP53RK, C20orf64, BUD32, DJ101A2.2, DJ101A2, Nori-2p, p53-related protein kinase, PRPK, TP53-regulating kinase, Nori-2, TP53 regulating kinase |
Target Sequences: | NM_033550 NP_291028.3 Q96S44 |
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