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PRPH2

peripherin 2 (retinal degeneration, slow)

PRPH2 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein found in the outer segment of both rod and cone photoreceptor cells. It may function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. This protein is essential for disk morphogenesis. Defects in this gene are associated with both central and peripheral retinal degenerations. Some of the various phenotypically different disorders are autosomal dominant retinitis pigmentosa, progressive macular degeneration, macular dystrophy and retinitis pigmentosa digenic.

Gene Name: peripherin 2 (retinal degeneration, slow)
Synonyms: PRPH2, AOFMD, AVMD, CACD2, DS, Peripherin, photoreceptor type, Peripherin-2, Peripherin 2, homolog of mouse, Rd2, Retinal degeneration, slow, Retinal peripherin, Tetraspanin-22, TSPAN22, RDS, RP7, Tspan-22
Target Sequences: NM_000322 NP_000313.2 P23942

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Proteins (3)
Over-Expression Lysate (2)
Recombinant (1)
PRPH2 (3)
No (3)
Myc-DDK (Flag) (3)
Human (2)
293T Cells (1)
HEK 293 Cells (2)
PRPH2 Protein - Purified recombinant protein PRPH2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
39.1 kDa
20 µg/$1,107
PRPH2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
39.1 kDa
20 µg/$150
PRPH2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
39.1 kDa
100 µg/$494
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).