PRPF19 / PRP19

pre-mRNA processing factor 19

Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex (PubMed:20595234). Recruited to RNA polymerase II C-terminal domain (CTD) and the pre-mRNA, it may also couple the transcriptional and spliceosomal machineries (PubMed:21536736). The XAB2 complex, which contains PRPF19, is also involved in pre-mRNA splicing, transcription and transcription-coupled repair (PubMed:17981804). Beside its role in pre-mRNA splicing PRPF19, as part of the PRP19-CDC5L complex, plays a role in the DNA damage response/DDR. It is recruited to the sites of DNA damage by the RPA complex where PRPF19 directly ubiquitinates RPA1 and RPA2. 'Lys-63'-linked polyubiquitination of the RPA complex allows the recruitment of the ATR-ATRIP complex and the activation of ATR, a master regulator of the DNA damage response (PubMed:24332808). May also play a role in DNA double-strand break (DSB) repair by recruiting the repair factor SETMAR to altered DNA (PubMed:18263876). As part of the PSO4 complex may also be involved in the DNA interstrand cross-links/ICLs repair process (PubMed:16223718). In addition, may also mediate 'Lys-48'-linked polyubiquitination of substrates and play a role in proteasomal degradation (PubMed:11435423). May play a role in the biogenesis of lipid droplets (By similarity). May play a role in neural differentiation possibly through its function as part of the spliceosome.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

PRPF19 / PRP19 (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human PRPF19 / PRP19 Protein (Recombinant GST, N-terminus) (aa1-90) - LS-G62275

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PRPF19 / PRP19 Protein (Recombinant GST) (Full Length) - LS-G33339

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

81.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PRPF19 / PRP19 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69814

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55 kDa

Price:

20 µg/$1,107

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Human PRPF19 / PRP19 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85604

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55 kDa

Price:

20 µg/$150

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PRPF19 / PRP19 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101227

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55 kDa

Price:

100 µg/$494

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