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Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to the yeast splicing factor Prp18.
Gene Name: | pre-mRNA processing factor 18 |
Synonyms: | PRPF18, HPrp18, PRP18, PRP18 homolog, Pre-mRNA-splicing factor 18 |
Target Sequences: | NM_003675 NP_003666.1 Q99633 |
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