Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.
|Gene Name:||prospero homeobox 1|
|Synonyms:||PROX1, Prospero-related homeobox 1, Prospero homeobox 1, PROX-1, Prospero homeobox protein 1|
|Target Sequences:||NM_002763 NP_002754.2 Q92786|
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