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PROX1
prospero homeobox 1
Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.
| Gene Name: | prospero homeobox 1 |
| Synonyms: | PROX1, Prospero-related homeobox 1, Prospero homeobox 1, PROX-1, Prospero homeobox protein 1 |
| Target Sequences: | NM_002763 NP_002754.2 Q92786 |
![PROX1 Antibody - Immunofluorescence of monoclonal antibody to PROX1 on HeLa cell . [antibody concentration 10 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/prox1-antibody-clone-1e7-ls-c198008/146236_4905545.jpg)
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