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Proteoglycan 4 / Lubricin

proteoglycan 4

Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface.Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages.

Gene Name: proteoglycan 4
Synonyms: PRG4, BG174L6.2, CACP, HAPO, JCAP, Proteoglycan 4, Superficial zone proteoglycan, SZP, Lubricin, MSF
Target Sequences: NM_005807 NP_005798.3 Q92954

Publications (2)

1
Role of Fibulin 3 in Aging-Related Joint Changes and Osteoarthritis Pathogenesis in Human and Mouse Knee Cartilage. Hasegawa A, Yonezawa T, Taniguchi N, Otabe K, Akasaki Y, Matsukawa T, Saito M, Neo M, Marmorstein LY, Lotz MK. Arthritis and rheumatism. 2017 March;69:576-585. (Human) [Full Text Article] [PubMed:27780308] [PMC:PMC5328782]
2
Hyaline cartilage differentiation of fibroblasts in regeneration and regenerative medicine. Ling Yu, Yu-Lieh Lin, Mingquan Yan, Tao Li, Emily Y Wu, Katherine Zimmel, Osama Qureshi, Alyssa Falck, Kirby M Sherman, Shannon S Huggins, Daniel Osorio Hurtado, Larry J Suva, Dana Gaddy, James Cai, Regina Brunauer, Lindsay A Dawson, Ken Muneoka. Development (Cambridge, England). 2022 January;149:dev200249. [Full Text Article] [PubMed:35005773] [PMC:PMC8917415]

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Proteins (2)
Recombinant (2)
Proteoglycan 4 / Lubricin (2)
No (2)
6His, N-terminus (1)
GST, N-terminus (1)
Human (2)
E. coli (1)
Wheat Germ Extract (1)
Proteoglycan 4 / Lubricin Protein - Recombinant Proteoglycan 4 By SDS-PAGE
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E. coli
6His, N-terminus
11.6 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
Proteoglycan 4 / Lubricin Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
2 µg/$439
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).