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PROM1 / CD133

prominin 1

May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617). Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner (PubMed:20818439).

Gene Name: prominin 1
Synonyms: PROM1, Antigen AC133, CD133, CD133 antigen, CORD12, AC133, HProminin, Macular dystrophy, retinal 2, MCDR2, Prominin-1, Prominin (mouse)-like 1, Prominin-like protein 1, RP41, Prominin 1, STGD4, MSTP061, PROML1
Target Sequences: NM_006017 NP_006008.1 O43490

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).