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May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617). Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner (PubMed:20818439).
Gene Name: | prominin 1 |
Synonyms: | PROM1, Antigen AC133, CD133, CD133 antigen, CORD12, AC133, HProminin, Macular dystrophy, retinal 2, MCDR2, Prominin-1, Prominin (mouse)-like 1, Prominin-like protein 1, RP41, Prominin 1, STGD4, MSTP061, PROML1 |
Target Sequences: | NM_006017 NP_006008.1 O43490 |
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