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Prohibitin 2 / PHB2

prohibitin 2

Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases By similarity. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging.

Gene Name:	prohibitin 2
Family/Subfamily:	Transcription factor
Synonyms:	PHB2, BCAP37, BAP, D-prohibitin, p22, Prohibitin-2, B-cell associated protein, Bap37, PNAS-141, Prohibitin 2, REA
Target Sequences:	NM_007273 NP_001138303.1 Q99623

Publications (2)

Identification of the cellular prohibitin 1/prohibitin 2 heterodimer as an interaction partner of the C-terminal cytoplasmic domain of the HIV-1 glycoprotein. Emerson V, Holtkotte D, Pfeiffer T, Wang IH, Schnlzer M, Kempf T, Bosch V. Journal of virology. 2010 84:1355-65. [PubMed:19906925] [PMC:PMC2812343] Related Antibodies: LS-B1889.

Prohibitins and the cytoplasmic domain of CD86 cooperate to mediate CD86 signaling in B lymphocytes. Lucas CR, Cordero-Nieves HM, Erbe RS, McAlees JW, Bhatia S, Hodes RJ, Campbell KS, Sanders VM. Journal of immunology (Baltimore, Md. : 1950). 2013 190:723-36. [PubMed:23241883] [PMC:PMC3538926] Related Antibodies: LS-B1889.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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