PRMT6

protein arginine methyltransferase 6

Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53. Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7 (NC).

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Products

Antibodies (38)

Proteins (9)

Type

Over-Expression Lysate (4)

Primary (38)

Recombinant (5)

Target

PRMT6 (47)

Reactivity

Human (37)

Mouse (6)

Rat (9)

Bovine (3)

Chimpanzee (3)

Dog (6)

Gibbon (6)

Guinea pig (4)

Horse (3)

Monkey (8)

Monkey-Rhesus (1)

Non-Human Primate (1)

Orangutan (6)

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Application

IHC (15)

IHC-P (7)

WB (29)

ELISA (13)

ICC (4)

IF (4)

IP (2)

Peptide-ELISA (1)

Host

rabbit (29)

mouse (7)

goat (1)

rabbit-new zealand white (1)

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IHCPlus (1)

Isotype

IgG (16)

IgG1 (3)

Clonality

monoclonal mc (7)

polyclonal pc (31)

Clone

4G2 (2)

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Biotin Conjugated (4)

FITC Conjugated (4)

HRP Conjugated (4)

Preservative Free (1)

Unconjugated (26)

Epitope

C-Terminus (4)

aa275-324 (4)

aa325-C-term (2)

aa1-50 (1)

aa19-48 (1)

aa42-53 (1)

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No (47)

Tag

GST (1)

GST, N-terminus (1)

His-DDK (Flag) (1)

Myc-DDK (Flag) (6)

Species

Human (7)

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293T Cells (2)

HEK 293 Cells (4)

Human Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (1)

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IHC-plus™ PRMT6 Antibody LS-B118

(4.0) Rating

Antibody:

PRMT6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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PRMT6 Antibody LS-C178302

Antibody:

PRMT6 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ICC, IHC, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

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PRMT6 Antibody LS-C393488

Antibody:

PRMT6 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$391

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PRMT6 Antibody LS-C682238

Antibody:

PRMT6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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PRMT6 Antibody LS-C379189

Antibody:

PRMT6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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PRMT6 Antibody (HRP) LS-C379195

Antibody:

PRMT6 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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PRMT6 Antibody (Biotin) LS-C379196

Antibody:

PRMT6 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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PRMT6 Antibody (FITC) LS-C379197

Antibody:

PRMT6 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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PRMT6 Antibody LS-C813099

Antibody:

PRMT6 Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$406; 200 µg/$505

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PRMT6 Antibody (Preservative Free) LS-C815690

Antibody:

PRMT6 Rabbit anti-Human Polyclonal (Preservative Free) Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC-P

Format:

Unconjugated, Preservative Free

Price:

100 µl/$412

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PRMT6 Antibody (aa19-48) LS-C96514

Antibody:

PRMT6 Rabbit anti-Human Polyclonal (aa19-48) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

PRMT6 Antibody LS-C753382

Antibody:

PRMT6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$351

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PRMT6 Antibody LS-C484649

Antibody:

PRMT6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF

Format:

Unconjugated

Price:

100 µl/$412

Select

PRMT6 Antibody LS-C813101

Antibody:

PRMT6 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

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PRMT6 Antibody (aa325-C-term) LS-C287767

Antibody:

PRMT6 Rabbit anti-Human Polyclonal (aa325-C-term) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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PRMT6 Antibody LS-C409363

Antibody:

PRMT6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$287; 50 µl/$341; 100 µl/$431; 200 µl/$539

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PRMT6 Antibody LS-C484650

Antibody:

PRMT6 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$412

Select

PRMT6 Antibody (clone 4G2) LS-C169197

Antibody:

PRMT6 Mouse anti-Human Monoclonal (4G2) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$435

Select

PRMT6 Antibody (aa325-C-term) LS-C286702

Antibody:

PRMT6 Rabbit anti-Human Polyclonal (aa325-C-term) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

0.5 µg/$295; 100 µl/$532

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PRMT6 Antibody LS-C829344

Antibody:

PRMT6 Rabbit-New Zealand White anti-Monkey-Rhesus Polyclonal Antibody

Reactivity:

Rat, Monkey-Rhesus, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$393

Select

PRMT6 Antibody LS-C484652

Antibody:

PRMT6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

100 µl/$412

Select

PRMT6 Antibody (aa42-53) LS-C155021

Antibody:

PRMT6 Goat anti-Human Polyclonal (aa42-53) Antibody

Reactivity:

Mouse, Guinea pig, Rat, Human, Monkey

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

Select

PRMT6 Antibody (clone 4G2) LS-C758810

Antibody:

PRMT6 Mouse anti-Human Monoclonal (4G2) Antibody

Reactivity:

Human, Non-Human Primate

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$541

Select

PRMT6 Antibody LS-C484651

Antibody:

PRMT6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

100 µl/$412

Select

PRMT6 Antibody LS-C769865

Antibody:

PRMT6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

60 µl/$343; 120 µl/$427; 200 µl/$559

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