PRMT5

protein arginine methyltransferase 5

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation. Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9. Methylates and regulates SRGAP2 which is involved in cell migration and differentiation. Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter.

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Proteins (8)

Type

Over-Expression Lysate (4)

Recombinant (4)

Target

PRMT5 (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (1)

His-DDK (Flag) (1)

Myc-DDK (Flag) (5)

Species

Human (6)

Source

293T Cells (2)

HEK 293 Cells (3)

Human Cells (1)

Wheat Germ Extract (2)

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Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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Human PRMT5 Protein (Recombinant GST, N-terminus) (aa531-637) - LS-G61502

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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PRMT5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115510

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

72.5 kDa

Price:

100 µg/$494

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PRMT5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G120644

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

71.1 kDa

Price:

100 µg/$710

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Human PRMT5 Protein (Recombinant GST) (Full Length) - LS-G32133

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

95.81 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PRMT5 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67589

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

72.5 kDa

Price:

20 µg/$1,107

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Human PRMT5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80233

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

71.1 kDa

Price:

20 µg/$215

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Human PRMT5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80234

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

72.5 kDa

Price:

20 µg/$150

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Human PRMT5 Protein (Recombinant His-DDK (Flag)) (Ala2-Leu637) - LS-G97795

Source:

Human Cells

Tag:

His-DDK (Flag)

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

75 kDa

Price:

50 µg/$721

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