PRMT4 / CARM1

coactivator-associated arginine methyltransferase 1

Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

PRMT4 / CARM1 (4)

Publications

No (4)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Human PRMT4 / CARM1 Protein (Recombinant GST, N-terminus) (aa284-381) - LS-G61533

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PRMT4 / CARM1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87776

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.7 kDa

Price:

20 µg/$215

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Human PRMT4 / CARM1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70702

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.7 kDa

Price:

20 µg/$1,107

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PRMT4 / CARM1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G103517

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.7 kDa

Price:

100 µg/$710

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