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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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PRMT2
protein arginine methyltransferase 2
Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation.
| Gene Name: | protein arginine methyltransferase 2 |
| Synonyms: | PRMT2, HMT1, HRMT1L1, PRMT2 alpha, PRMT2 beta, Arginine N-methyltransferase 2, PRMT2 gamma |
| Target Sequences: | NM_001535 NP_001526.2 P55345 |
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