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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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PRKRA / PACT
protein kinase, interferon-inducible double stranded RNA dependent activator
Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner.
| Gene Name: | protein kinase, interferon-inducible double stranded RNA dependent activator |
| Synonyms: | PRKRA, DYT16, HSD14, PKR-associating protein X, PACT, PKR-associated protein X |
| Target Sequences: | NM_003690 NP_003681.1 O75569 |
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