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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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PRKCZ / PKC-Zeta

protein kinase C, zeta

Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Necessary and sufficient for LTP maintenance in hippocampal CA1 pyramidal cells. In vein endothelial cells treated with the oxidant peroxynitrite, phosphorylates STK11 leading to nuclear export of STK11, subsequent inhibition of PI3K/Akt signaling, and increased apoptosis.

Gene Name: protein kinase C, zeta
Family/Subfamily: Protein Kinase , PKC
Synonyms: PRKCZ, PKC-ZETA, PKC2, Pkcz, PKCzeta, Protein kinase c zeta, Protein kinase C zeta type, NPKC-zeta, PKC Zeta, Protein kinase C, zeta, Protein kinase Czeta
Target Sequences: NM_002744 NP_002735.3 Q05513

Filtered by: None
Target
PRKCZ / PKC-Zeta (103)
Reactivity
Human (73)
Mouse (53)
Rat (30)
Bovine (6)
Chicken (2)
Dog (6)
Drosophila (2)
Gibbon (3)
Guinea pig (4)
Horse (6)
Mammal (1)
Monkey (10)
Orangutan (3)
Rabbit (4)
Rodent (1)
Xenopus (2)
Zebrafish (4)
Application
IHC (49)
IHC-Fr (1)
IHC-P (28)
WB (81)
Flo (1)
ELISA (52)
ICC (4)
IF (19)
IP (11)
Peptide-ELISA (3)
RIA (1)
RNAi (1)
Host
rabbit (102)
mouse (1)
Isotype
IgG (57)
IgG2b,k (1)
Clonality
monoclonal mc (2)
polyclonal pc (101)
Clone
2D1 (1)
EP1490(2) (1)
S19-V (1)
Format
AP Conjugated (5)
APC (2)
APC Conjugated (7)
Azide-free (4)
Biotin Conjugated (9)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (10)
HRP Conjugated (9)
PE Conjugated (7)
Unconjugated (52)
Epitope
N-Terminus (11)
aa1-30 (8)
aa166-197 (8)
aa254-484 (8)
aa404-591 (8)
Cytoplasmic Domain (7)
pThr410 (7)
pThr560 (4)
C-Terminus (3)
350-430 aa (2)
500-580 aa (2)
Internal (2)
Pro404 (1)
Pro556 (1)
aa376-425 (1)
aa577-592 (1)
aa579-592 (1)
pThr410/Thr403 (1)
Publications
No (103)
Showing 1-25 of 103 results

IHC-plus™ PRKCZ / PKC-Zeta Antibody (Cytoplasmic Domain) LS-A8391
Rabbit Polyclonal to Human PRKCZ / PKC-Zeta
Human
ELISA, IHC, IHC-P
Unconjugated
50µg 1mg/ml  $425.00
Anti-PRKCZ / PKC-Zeta antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-PRKCZ / PKC-Zeta antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ PRKCZ / PKC-Zeta Antibody (Cytoplasmic Domain, APC) LS-A107832
Rabbit Polyclonal to Human PRKCZ / PKC-Zeta
Human
ELISA, IHC, IHC-P
APC Conjugated
100µl  $650.00
Anti-PRKCZ / PKC-Zeta antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-PRKCZ / PKC-Zeta antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ PRKCZ / PKC-Zeta Antibody (Internal, clone EP1490(2)) LS-B6294
Rabbit Monoclonal [clone EP1490(2)] to Human PRKCZ / PKC-Zeta
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50µl  $425.00
Anti-PRKCZ / PKC-Zeta antibody IHC of human brain cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Western blot analysis on (A) 293T, (B) HT-29, and (C) fetal liver lysates using PKC zeta antibody.

IHC-plus™ PRKCZ / PKC-Zeta Antibody (N-Terminus) LS-A8392
Rabbit Polyclonal to Human PRKCZ / PKC-Zeta
Human
ELISA, IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-PRKCZ / PKC-Zeta antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

PRKCZ / PKC-Zeta Antibody (C-Terminus) LS-C354069
Rabbit Polyclonal to Human PRKCZ / PKC-Zeta
Zebrafish, Rat, Rabbit, Mouse, Human, Monkey
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100µl 1mg/ml  $245.00
Immunohistochemical analysis of PKC zeta staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of PKC zeta staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).

IHC-plus™ PRKCZ / PKC-Zeta Antibody (aa376-425) LS-B12514
Rabbit Polyclonal (IgG) to Human PRKCZ / PKC-Zeta
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100µl 1mg/ml  $505.00
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)

PRKCZ / PKC-Zeta Antibody (phospho-Thr410) LS-C177941
Rabbit Polyclonal to Human PRKCZ / PKC-Zeta
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
100µl  $345.00
IHC of p-PKC (T410) pAb in paraffin-embedded human lung carcinoma tissue.
Western blot of p-PKC (T410) pAb in extracts from NIH/3T3 cells.

PRKCZ / PKC-Zeta Antibody (500-580 aa) LS-C380826
Rabbit Polyclonal (IgG) to Human PRKCZ / PKC-Zeta
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00
Western blot of Phospho-PKC zeta (T560) antibody

PRKCZ / PKC-Zeta Antibody LS-C83670
Rabbit Polyclonal to Human PRKCZ / PKC-Zeta
Mouse, Rat, Human
ELISA, IP, WB
Unconjugated
50µl  $295.00; 100µl  $375.00

PRKCZ / PKC-Zeta Antibody (phospho-Thr410) LS-C416778
Rabbit Polyclonal to Human PRKCZ / PKC-Zeta
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
100µg  $305.00
Western blot of PKC zeta phosphorylation expression in PMA treated NIH-3T3 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.

PRKCZ / PKC-Zeta Antibody LS-C417603
Rabbit Polyclonal to Human PRKCZ / PKC-Zeta
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
100µg  $305.00
Western blot of PKC zeta expression in PMA treated COS7 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.

PRKCZ / PKC-Zeta Antibody (phospho-Thr410) LS-C199456
Rabbit Polyclonal (IgG) to Human PRKCZ / PKC-Zeta
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using PKC zeta (Phospho-Thr410) Antibody. The picture on the right is blocked with the phospho peptide.
Immunofluorescence analysis of HeLa cells, using PKC zeta (Phospho-Thr410) Antibody. The picture on the right is blocked with the phospho peptide.

PRKCZ / PKC-Zeta Antibody LS-C658493
Rabbit Polyclonal (IgG) to Human PRKCZ / PKC-Zeta
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl  $445.00

PRKCZ / PKC-Zeta Antibody (phospho-Thr560) LS-C801153
Rabbit Polyclonal (IgG) to Human PRKCZ / PKC-Zeta
Mouse, Rat, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00

PRKCZ / PKC-Zeta Antibody (phospho-Thr410) LS-C801151
Rabbit Polyclonal (IgG) to Human PRKCZ / PKC-Zeta
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00

PRKCZ / PKC-Zeta Antibody LS-C808679
Rabbit Polyclonal (IgG) to Human PRKCZ / PKC-Zeta
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00

PRKCZ / PKC-Zeta Antibody (350-430 aa) LS-C385538
Rabbit Polyclonal (IgG) to Human PRKCZ / PKC-Zeta
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00
Western blot of PKC zeta antibody

PRKCZ / PKC-Zeta Antibody (350-430 aa) LS-C380825
Rabbit Polyclonal (IgG) to Human PRKCZ / PKC-Zeta
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00
Western blot of Phospho-PKC zeta (T410) antibody
Western blot of Phospho-PKC zeta (T410) antibody

PRKCZ / PKC-Zeta Antibody (500-580 aa) LS-C385540
Rabbit Polyclonal (IgG) to Human PRKCZ / PKC-Zeta
Mouse, Rat, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00
Western blot of PKC zeta antibody
Western blot of PKC zeta antibody

PRKCZ / PKC-Zeta Antibody (Pro404) LS-C176181
Rabbit Polyclonal to Human PRKCZ / PKC-Zeta
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
100µl  $345.00
IHC of PKC (P404) pAb in paraffin-embedded human lung carcinoma tissue.
Western blot of PKC (P404) pAb in extracts from A549 cells.

PRKCZ / PKC-Zeta Antibody (Pro556) LS-C176454
Rabbit Polyclonal to Human PRKCZ / PKC-Zeta
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
100µl  $345.00
IHC of PKC (P556) pAb in paraffin-embedded human brain tissue.
Western blot of PKC (P556) pAb in extracts from COS7 cells treated with PMA 125ng/ml 30'.

PRKCZ / PKC-Zeta Antibody LS-C769473
Rabbit Polyclonal (IgG) to Human PRKCZ / PKC-Zeta
Mouse, Rat, Human
ELISA, IF, IHC-P, WB
Unconjugated
20µl 1mg/ml  $205.00; 60µl 1mg/ml  $235.00; 120µl 1mg/ml  $295.00; 200µl 1mg/ml  $395.00

PRKCZ / PKC-Zeta Antibody (phospho-Thr410/Thr403) LS-C26210
Rabbit Polyclonal (IgG) to Human PRKCZ / PKC-Zeta
Mouse, Rat, Human, Monkey
ELISA, IHC, IHC-P, WB
Unconjugated
100µl  $575.00

PRKCZ / PKC-Zeta Antibody (aa579-592) LS-C26209
Rabbit Polyclonal (IgG) to Rat PRKCZ / PKC-Zeta
Mouse, Rat
ELISA, ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100µl  $435.00

PRKCZ / PKC-Zeta Antibody LS-C26200
Rabbit Polyclonal (IgG) to Human PRKCZ / PKC-Zeta
Human
IHC, IHC-P, IP, WB
Unconjugated
100µl  $530.00
Showing 1-25 of 103 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).