PRKCG / PKC-Gamma

protein kinase C, gamma

Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

PRKCG / PKC-Gamma (5)

Publications

No (5)

Tag

GST, N-terminus (1)

His-S (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Rat (1)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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PRKCG / PKC-Gamma Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117790

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

78.3 kDa

Price:

100 µg/$494

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Human PRKCG / PKC-Gamma Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66709

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

78.3 kDa

Price:

20 µg/$1,107

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Human PRKCG / PKC-Gamma Protein (Recombinant GST, N-terminus) (aa260-351) - LS-G59729

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PRKCG / PKC-Gamma Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78338

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

78.3 kDa

Price:

20 µg/$150

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Rat PRKCG / PKC-Gamma Protein (Recombinant His-S) (aa351-614) - LS-G12149

Source:

E. coli

Tag:

His-S

Molecular Weight:

35.3 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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