Menu
Products
Services
Research Areas
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Services
Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, froforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

PRKCG / PKC-Gamma

protein kinase C, gamma

Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage.

Gene Name: protein kinase C, gamma
Family/Subfamily: Protein Kinase , PKC
Synonyms: PRKCG, PKC-gamma, PRKC-gamma, Protein kinase C gamma, Protein kinase C gamma type, PKC Gamma, PKCC, PKCG, Pkcgamma, Protein kinase C, gamma, SCA14
Target Sequences: NM_002739 NP_002730.1 P05129

Publications (1)

1
Extracellular Lactate Dehydrogenase A Release From Damaged Neurons Drives Central Nervous System Angiogenesis. Lin H, Muramatsu R, Maedera N, Tsunematsu H, Hamaguchi M, Koyama Y, Kuroda M, Ono K, Sawada M, Yamashita T. EBioMedicine. 2018 January;27:71-85. (Human) [Full Text Article] [PubMed:29248508] [PMC:PMC5828296] Related Antibodies: LS-C91497.

Viewing 1-25 of 103 items
PRKCG / PKC-Gamma Antibody - Anti-PRKCG / PKC-Gamma antibody IHC of human brain, cerebellum, Purkinje cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Select
Rabbit Polyclonal (IgG) to Human PRKCG / PKC-Gamma
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50µl   1mg/ml   $425.00
Select
Mouse Monoclonal [clone PKC66] (IgG1) to Rat PRKCG / PKC-Gamma
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
200µg   $635.00
Select
Mouse Monoclonal (IgG1) to Rat PRKCG / PKC-Gamma
Mouse, Rat, Human
ELISA, IHC, WB
Biotin Conjugated
100µl   $815.00
Select
(1) Publication(s)
Rabbit Polyclonal (IgG) to Human PRKCG / PKC-Gamma
Mouse, Human
ELISA, WB
Unconjugated
40µg   $405.00
PRKCG / PKC-Gamma Antibody - Formalin-fixed and paraffin-embedded human brain tissue reacted with PKC gamma antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Select
Rabbit Polyclonal to Human PRKCG / PKC-Gamma
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
Select
Rabbit Polyclonal (IgG) to Human PRKCG / PKC-Gamma
Mouse, Human
ELISA, IHC, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human PRKCG / PKC-Gamma
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PRKCG / PKC-Gamma
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PRKCG / PKC-Gamma
Mouse, Human
ELISA, IHC, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PRKCG / PKC-Gamma
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PRKCG / PKC-Gamma
Mouse, Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PRKCG / PKC-Gamma
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200µl   $740.00
PRKCG / PKC-Gamma Antibody - Western blot of PKC-gamma in mouse brain crude lysate (50 ug of protein loaded).
Select
Rabbit Polyclonal to Human PRKCG / PKC-Gamma
Mouse, Rat, Human
ELISA, IP, WB
Unconjugated
50µl   $305.00; 100µl   $405.00
PRKCG / PKC-Gamma Antibody - Western blot of PKC gamma antibody
Select
Rabbit Polyclonal (IgG) to Human PRKCG / PKC-Gamma
Mouse, Rat, Human
ELISA, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Rabbit Polyclonal (IgG) to Human PRKCG / PKC-Gamma
Human
ELISA, Flo, IF, IHC, IP, WB
Unconjugated
100µg   $335.00
PRKCG / PKC-Gamma Antibody - PRKCG / PKC-Gamma antibody Western blot of 293T cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human PRKCG / PKC-Gamma
Zebrafish, Rat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Gibbon, Human, Monkey, Chimpanzee
WB
FITC Conjugated
100µl   1mg/ml   $385.00
Select
Rabbit Polyclonal (IgG) to Rat PRKCG / PKC-Gamma
Mouse, Rat, Human, Monkey
ELISA, ICC, IHC, IHC-Fr, WB
Unconjugated
100µl   $435.00
PRKCG / PKC-Gamma Antibody
Select
Rabbit Polyclonal (IgG) to Human PRKCG / PKC-Gamma
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal (IgG) to Human PRKCG / PKC-Gamma
Human
ICC, IHC, WB
Unconjugated
100µl   $415.00
Select
Rabbit Polyclonal (IgG) to Human PRKCG / PKC-Gamma
Mammal, Human
ELISA, IHC, WB
Unconjugated
100µl   $435.00
PRKCG / PKC-Gamma Antibody - Western blot analysis of extracts from Rat brain cells, using PRKCG(Ab-655) antibody.
Select
Rabbit Polyclonal (IgG) to Human PRKCG / PKC-Gamma
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µg   $305.00
PRKCG / PKC-Gamma Antibody - IHC staining of FFPE human glioma with PKC gamma antibody at 1ug/ml. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.
Select
Rabbit Polyclonal (IgG) to Human PRKCG / PKC-Gamma
Mouse, Rat, Human
IHC-P, WB
Unconjugated
100µg   $435.00
PRKCG / PKC-Gamma Antibody - Immunofluorescent analysis of Hela cells using PRKCG Antibody at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Select
Rabbit Polyclonal (IgG) to Human PRKCG / PKC-Gamma
Human
ELISA, IF
Unconjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human PRKCG / PKC-Gamma
Mammal, Rodent, Human
IF, WB
Unconjugated
1ml   $560.00
Select
Rabbit Polyclonal (IgG) to Mouse PRKCG / PKC-Gamma
Mouse
ELISA, WB
Unconjugated
200µl   $590.00

Viewing 1-25 of 103 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).