PRKCE / PKC-Epsilon

protein kinase C, epsilon

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1.

☰ Filters

Products

ELISA Kits (21)

Type

Cell-Based (1)

Cell-Based Phosphorylation (1)

Competitive EIA (1)

Custom (2)

Development Kit (3)

Sandwich (11)

Sandwich CLIA (2)

Target

PRKCE / PKC-Epsilon (21)

Reactivity

Human (10)

Mouse (7)

Rat (7)

Monkey (1)

Product Group

DevKit DuoPlus (3)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (5)

96-Well Strip Plate (12)

Antibody Pair and Standard (3)

Publications

No (21)

Sample Type

Adherent Cell Cultures (2)

Cell Culture Supernatants (3)

Cell Lysates (4)

Plasma (9)

Serum (9)

Tissue Homogenates (10)

Select

Rat PRKCE / PKC-Epsilon (Sandwich ELISA) ELISA Kit - LS-F37136

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Mouse/Human/Rat Phospho-PRKCE / PKC-Epsilon (Ser729) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1303

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

Select

Human PRKCE / PKC-Epsilon (Sandwich ELISA) ELISA Kit - LS-F35681

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

1.56 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

DevKit DuoPlus Human PRKCE / PKC-Epsilon ELISA Development Kit - LS-F71570

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Human

Range:

3.12 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

500 Wells/$1,182; 1000 Wells/$1,747

Select

Monkey PRKCE / PKC-Epsilon (Sandwich ELISA) ELISA Kit - LS-F47370

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

Select

Human PRKCE / PKC-Epsilon (Sandwich ELISA) ELISA Kit - LS-F20700

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

1.563 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

Select

Rat PRKCE / PKC-Epsilon (Custom ELISA) ELISA Kit - LS-F20201

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Mouse PRKCE / PKC-Epsilon (Custom ELISA) ELISA Kit - LS-F20202

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Mouse PRKCE / PKC-Epsilon (Sandwich ELISA) ELISA Kit - LS-F22253

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

Select

Human PRKCE / PKC-Epsilon (CLIA) ELISA Kit - LS-F29774

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

Select

Mouse/Human/Rat PRKCE / PKC-Epsilon (Cell-Based ELISA) ELISA Kit - LS-F2250

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

Select

Rat PRKCE / PKC-Epsilon (Sandwich ELISA) ELISA Kit - LS-F21596

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

Select

Human PRKCE / PKC-Epsilon (CLIA) ELISA Kit - LS-F26485

Type:

Sandwich CLIA

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.14 - 100 ng/ml

Detection:

Chemiluminescent

Sample Types:

Tissue Homogenates

Price:

1 Plate/$968

Select

Human PRKCE / PKC-Epsilon (Competitive EIA) ELISA Kit - LS-F27773

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

5 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$913

Select

Mouse PRKCE / PKC-Epsilon (Sandwich ELISA) ELISA Kit - LS-F37137

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

DevKit DuoPlus Rat PRKCE / PKC-Epsilon ELISA Development Kit - LS-F71913

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Rat

Range:

3.12 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

500 Wells/$1,254; 1000 Wells/$1,867

Select

DevKit DuoPlus Mouse PRKCE / PKC-Epsilon ELISA Development Kit - LS-F71663

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Mouse

Range:

3.12 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

500 Wells/$1,207; 1000 Wells/$1,787

Select

Human PRKCE / PKC-Epsilon (Sandwich ELISA) ELISA Kit - LS-F4287

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

1.56 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$764

Select

Mouse PRKCE / PKC-Epsilon (Sandwich ELISA) ELISA Kit - LS-F4288

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$782

Select

Rat PRKCE / PKC-Epsilon (Sandwich ELISA) ELISA Kit - LS-F9167

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$818

Select

Human PRKCE / PKC-Epsilon (Sandwich ELISA) ELISA Kit - LS-F11901

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

1.56 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

Viewing 1-21 of 21 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: ELISA Kits

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.