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PRKCB / PKC-Beta

protein kinase C, beta

Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription.

Gene Name: protein kinase C, beta
Family/Subfamily: Protein Kinase , PKC
Synonyms: PRKCB, PKC beta 2, Pkc betaII, PRKCB2, Protein kinase c beta, Protein kinase c beta 2, Protein kinase c beta i, Protein kinase C beta type, Protein kinase C, beta, Protein kinase C, beta 1, PRKCB1, Pkc betaI, PKC-beta, PKCB, Pkcbeta, PkcbetaI, PKC-B, PkcbetaII, Protein kinase c beta 1, Protein kinase c beta II
Target Sequences: NM_002738 NP_002729.2 P05771

☰ Filters
Antibodies (100)
cDNAs (30)
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PRKCB / PKC-Beta (162)
Human (76)
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PRKCB / PKC-Beta Antibody - Anti-PRKCB / PKC-Beta antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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PRKCB / PKC-Beta Goat anti-Human Polyclonal (aa631-642) Antibody
Rabbit, Mouse, Bovine, Rat, Horse, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
PRKCB / PKC-Beta Antibody - Anti-PRKCB / PKC-Beta antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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PRKCB / PKC-Beta Rabbit anti-Human Polyclonal (aa606-655) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
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PRKCB / PKC-Beta Rabbit anti-Rat Polyclonal (aa660-673) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Horse, Bat, Human, Monkey
ELISA, IHC, IHC-Fr, WB
Unconjugated
100 µl/$474
PRKCB / PKC-Beta Antibody - Mouse Prkcb Antibody immunohistochemistry of formalin-fixed and paraffin-embedded mouse stomach tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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PRKCB / PKC-Beta Rabbit anti-Mouse Polyclonal (aa1-30) Antibody
Mouse
IHC, IHC-P, WB
Unconjugated
400 µl/$376
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PRKCB / PKC-Beta Rabbit anti-Rat Polyclonal Antibody
Rat
ELISA, IF, WB
Unconjugated
100 µl/$487
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PRKCB / PKC-Beta Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IP, WB
Unconjugated
50 µl/$348; 100 µl/$446
PRKCB / PKC-Beta Antibody - Western blot of PKC-betaII in mouse brain crude lysate (50 ug of protein loaded).
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PRKCB / PKC-Beta Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IP, WB
Unconjugated
50 µl/$348; 100 µl/$446
PRKCB / PKC-Beta Antibody - Immunohistochemistry image of paraffin-embedded human lung cancer at a dilution of 1:100
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PRKCB / PKC-Beta Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$284; 100 µg/$351
PRKCB / PKC-Beta Antibody - PRKCB / PKC-Beta antibody Western blot of Fetal Thymus lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PRKCB / PKC-Beta Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Bovine, Rat, Pig, Human, Monkey
WB
Unconjugated
100 µl/$434
PRKCB / PKC-Beta Antibody - PRKCB / PKC-Beta antibody Western blot of NCI-H226 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PRKCB / PKC-Beta Rabbit anti-Human Polyclonal (aa71-120) Antibody
Xenopus, Chicken, Zebrafish, Pig, Rabbit, Mouse, Guinea pig, Bovine, Rat, Human, Monkey
WB
Unconjugated
100 µl/$434
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PRKCB / PKC-Beta Rabbit anti-Human Polyclonal (FITC) (Q19-V) Antibody
Flo
FITC Conjugated
100 Tests/$512
PRKCB / PKC-Beta Antibody - Anti-PRKCB / PKC-Beta antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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PRKCB / PKC-Beta Rabbit anti-Human Polyclonal (aa621-670) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
PRKCB / PKC-Beta Antibody - Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue.
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PRKCB / PKC-Beta Rabbit anti-Human Polyclonal (pThr641) Antibody
IF, IHC, WB
Unconjugated
20 µl/$253; 50 µl/$306; 100 µl/$381; 200 µl/$489
PRKCB / PKC-Beta ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$730
PRKCB / PKC-Beta ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$721
PRKCB / PKC-Beta Antibody - Staining HeLa cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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PRKCB / PKC-Beta Rabbit anti-Human Polyclonal (pSer661) Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100 µl/$369; 200 µl/$411
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PRKCB / PKC-Beta Rabbit anti-Mouse Polyclonal (aa1-30) Antibody
Mouse
ELISA, IHC, WB
Unconjugated
200 µl/$614
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PRKCB / PKC-Beta Rabbit anti-Mouse Polyclonal (aa1-30) (AP) Antibody
Mouse
ELISA, IHC, WB
AP Conjugated
200 µl/$767
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PRKCB / PKC-Beta Rabbit anti-Mouse Polyclonal (aa1-30) (APC) Antibody
Mouse
ELISA, IHC, WB
APC Conjugated
200 µl/$767
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PRKCB / PKC-Beta Mouse anti-Rat Monoclonal Antibody
Rat, Human
Func, IF, IP, WB
Unconjugated
200 µg/$660
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PRKCB / PKC-Beta Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$396
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PRKCB / PKC-Beta Rabbit anti-Human Polyclonal (aa642-673) Antibody
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
Unconjugated
200 µl/$614
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PRKCB / PKC-Beta Rabbit anti-Human Polyclonal (aa303-334) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$614
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PRKCB / PKC-Beta Rabbit anti-Human Polyclonal (600-680 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
PRKCB / PKC-Beta Antibody - Staining HeLa cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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PRKCB / PKC-Beta Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100 µl/$369; 200 µl/$411
Viewing 1-25 of 162 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).