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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PRKCB / PKC-Beta

protein kinase C, beta

Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription.

Gene Name: protein kinase C, beta
Family/Subfamily: Protein Kinase , PKC
Synonyms: PRKCB, PKC beta 2, Pkc betaII, PRKCB2, Protein kinase c beta, Protein kinase c beta 2, Protein kinase c beta i, Protein kinase C beta type, Protein kinase C, beta, Protein kinase C, beta 1, PRKCB1, Pkc betaI, PKC-beta, PKCB, Pkcbeta, PkcbetaI, PKC-B, PkcbetaII, Protein kinase c beta 1, Protein kinase c beta II
Target Sequences: NM_002738 NP_002729.2 P05771

Viewing 1-25 of 103 items
PRKCB / PKC-Beta Antibody - Anti-PRKCB / PKC-Beta antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Goat Polyclonal to Human PRKCB / PKC-Beta
Rabbit, Mouse, Bovine, Rat, Horse, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg   0.5mg/ml   $425.00
PRKCB / PKC-Beta Antibody - Anti-PRKCB / PKC-Beta antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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Rabbit Polyclonal (IgG) to Human PRKCB / PKC-Beta
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $425.00
PRKCB / PKC-Beta Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal to Human PRKCB / PKC-Beta
Human
ELISA, IHC, IHC-P, WB
Unconjugated
40µg   0.5mg/ml   $425.00
PRKCB / PKC-Beta Antibody - Anti-PRKCB / PKC-Beta antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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Rabbit Polyclonal to Human PRKCB / PKC-Beta
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50µl   $425.00
PRKCB / PKC-Beta Antibody - Mouse Prkcb Antibody immunohistochemistry of formalin-fixed and paraffin-embedded mouse stomach tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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Rabbit Polyclonal to Mouse PRKCB / PKC-Beta
Mouse
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
Select
Rabbit Polyclonal to Rat PRKCB / PKC-Beta
Rat
ELISA, IF, WB
Unconjugated
100µl   $445.00
Select
Rabbit Polyclonal to Human PRKCB / PKC-Beta
Mouse, Rat, Human
ELISA, IP, WB
Unconjugated
50µl   $305.00; 100µl   $405.00
PRKCB / PKC-Beta Antibody - Western blot of PKC-betaII in mouse brain crude lysate (50 ug of protein loaded).
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Rabbit Polyclonal to Human PRKCB / PKC-Beta
Mouse, Rat, Human
ELISA, IP, WB
Unconjugated
50µl   $305.00; 100µl   $405.00
PRKCB / PKC-Beta Antibody - Immunohistochemistry image of paraffin-embedded human lung cancer at a dilution of 1:100
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Rabbit Polyclonal (IgG) to Human PRKCB / PKC-Beta
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg   $285.00; 100µg   $385.00
PRKCB / PKC-Beta Antibody - PRKCB / PKC-Beta antibody Western blot of Fetal Thymus lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal (IgG) to Human PRKCB / PKC-Beta
Mouse, Bovine, Rat, Pig, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $365.00
PRKCB / PKC-Beta Antibody - PRKCB / PKC-Beta antibody Western blot of NCI-H226 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal (IgG) to Human PRKCB / PKC-Beta
Xenopus, Chicken, Zebrafish, Pig, Rabbit, Mouse, Guinea pig, Bovine, Rat, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $365.00
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Rabbit Polyclonal [clone Q19-V] (IgG) to Human PRKCB / PKC-Beta
Flo
FITC Conjugated
100tst   $475.00
PRKCB / PKC-Beta Antibody - Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue.
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Rabbit Polyclonal (IgG) to Human PRKCB / PKC-Beta
IF, IHC, WB
Unconjugated
50µl   $265.00; 100µl   $375.00; 200µl   $495.00
Select
Rabbit Polyclonal (IgG) to Rat PRKCB / PKC-Beta
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Horse, Bat, Human, Monkey
ELISA, ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100µl   $435.00
PRKCB / PKC-Beta Antibody
Select
Rabbit Polyclonal (IgG) to Human PRKCB / PKC-Beta
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal (IgG) to Mouse PRKCB / PKC-Beta
Mouse
ELISA, IHC, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Mouse PRKCB / PKC-Beta
Mouse
ELISA, IHC, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Mouse PRKCB / PKC-Beta
Mouse
ELISA, IHC, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Mouse PRKCB / PKC-Beta
Mouse
ELISA, IHC, WB
PE Conjugated
200µl   $740.00
Select
Mouse Monoclonal (IgG1) to Rat PRKCB / PKC-Beta
Rat, Human
Func, IF, IP, WB
Unconjugated
200µg   $635.00
Select
Rabbit Polyclonal (IgG) to Human PRKCB / PKC-Beta
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Rabbit Polyclonal (IgG) to Human PRKCB / PKC-Beta
Human
ELISA, IHC, WB
Unconjugated
100µg   $355.00
Select
Rabbit Polyclonal (IgG) to Human PRKCB / PKC-Beta
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human PRKCB / PKC-Beta
Human
ELISA, IHC, WB
Unconjugated
200µl   $590.00
PRKCB / PKC-Beta Antibody
Select
Rabbit Polyclonal (IgG) to Human PRKCB / PKC-Beta
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00

Viewing 1-25 of 103 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).