PRKAR2B

protein kinase, cAMP-dependent, regulatory, type II, beta

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.

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Products

Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

PRKAR2B (4)

Publications

No (4)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Human PRKAR2B Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65160

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.1 kDa

Price:

20 µg/$1,107

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Human PRKAR2B Protein (Recombinant GST, N-terminus) (aa304-413) - LS-G59726

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PRKAR2B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74971

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.1 kDa

Price:

20 µg/$150

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PRKAR2B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117796

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.1 kDa

Price:

100 µg/$494

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