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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PRKAR1A

protein kinase, cAMP-dependent, regulatory, type I, alpha

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed.

Gene Name: protein kinase, cAMP-dependent, regulatory, type I, alpha
Family/Subfamily: Protein Kinase Non catalytic , CAMP
Synonyms: PRKAR1A, ADOHR, CNC, ACRDYS1, TSE1, PRKAR1, Tissue specific extinguisher 1, Tissue-specific extinguisher 1, CAR, CNC1, PKR1, PPNAD1
Target Sequences: NM_002734 NP_002725.1 P10644

Filtered By: None
Target
PRKAR1A (31)
Reactivity
Human (30)
Mouse (9)
Rat (13)
Bat (4)
Bovine (5)
Chicken (5)
Chimpanzee (6)
Dog (4)
Gibbon (6)
Guinea pig (9)
Hamster (5)
Horse (4)
Monkey (5)
Orangutan (6)
Pig (5)
Rabbit (5)
Sheep (5)
Xenopus (4)
Zebrafish (4)
Application
IHC (14)
IHC-P (6)
WB (31)
DB (2)
ELISA (9)
ICC (1)
IF (4)
IP (3)
Peptide-ELISA (1)
Host
rabbit (27)
mouse (4)
Isotype
IgG (15)
IgG1 (4)
Clonality
monoclonal mc (5)
polyclonal pc (26)
Clone
11C1062 (1)
3546C2a (2)
6C7 (1)
Format
AP Conjugated (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Unconjugated (19)
Epitope
aa1-30 (8)
C-Terminus (5)
aa51-100 (4)
240-320 aa, C-terminal (1)
aa1-50 (1)
aa271-320 (1)
aa50-100 (1)
Publications
No (31)
Showing 1-25 of 31 results

PRKAR1A Antibody IHC-plus™ LS-B14852
Rabbit Polyclonal (IgG) to Human PRKAR1A
Human
IF IHC IHC-P WB
Unconjugated
50µl  $425.00
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

PRKAR1A Antibody (C-Terminus) IHC-plus™ LS-B13583
Rabbit Polyclonal to Human PRKAR1A
Chicken, Sheep, Bovine, Rat, Pig, Mouse, Human
ICC IF IHC IHC-P WB
Unconjugated
50µl 1mg/ml  $425.00
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Immunofluorescent analysis of PRKAR1A staining in HT29 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
Immunofluorescent analysis of PRKAR1A staining in HT29 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).

PRKAR1A Antibody (aa1-30) LS-C101197
Rabbit Polyclonal to Human PRKAR1A
Human
IHC IHC-P WB
Unconjugated
400µl  $305.00
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Western blot of PKR1 (arrow) using rabbit polyclonal hPKR1-M1. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PKR1 gene (Lane 2). (2 ug/ml)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Western blot of PKR1 (arrow) using rabbit polyclonal hPKR1-M1. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PKR1 gene (Lane 2). (2 ug/ml)

PRKAR1A Antibody (clone 6C7) LS-C114736
Mouse Monoclonal [clone 6C7] (IgG1) to Human PRKAR1A
IF IHC IHC-P WB
Unconjugated
100µl  $345.00
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of breast tissue using anti-PRKAR1A mouse monoclonal antibody. (Dilution 1:50).
Immunohistochemical staining of paraffin-embedded colon tissue using anti-PRKAR1A mouse monoclonal antibody. (Dilution 1:50).
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of breast tissue using anti-PRKAR1A mouse monoclonal antibody. (Dilution 1:50).
Immunohistochemical staining of paraffin-embedded colon tissue using anti-PRKAR1A mouse monoclonal antibody. (Dilution 1:50).

PRKAR1A Antibody (clone 11C1062) LS-C184098
Rabbit Monoclonal [clone 11C1062] (IgG) to Human PRKAR1A
Mouse, Rat, Hamster, Human, Monkey
IP WB
Unconjugated
100µl  $530.00

PRKAR1A Antibody (C-Terminus) LS-C117130
Rabbit Polyclonal to Human PRKAR1A
Xenopus, Chicken, Zebrafish, Pig, Horse, Rat, Hamster, Bat, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey
WB
Unconjugated
50µg  $365.00
PRKAR1A antibody Western blot of Fetal Liver lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
PRKAR1A antibody Western blot of Fetal Liver lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

PRKAR1A Antibody (C-Terminus, Biotin) LS-C464159
Rabbit Polyclonal to Human PRKAR1A
Xenopus, Chicken, Zebrafish, Rat, Hamster, Pig, Horse, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Gibbon, Human, Monkey, Orangutan, Chimpanzee
WB
Biotin Conjugated
100µl 1mg/ml  $385.00
PRKAR1A antibody Western blot of Fetal Liver lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
PRKAR1A antibody Western blot of Fetal Liver lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

PRKAR1A Antibody (240-320 aa, C-terminal) LS-C385519
Rabbit Polyclonal (IgG) to Human PRKAR1A
Mouse, Rat, Human
ELISA IF IHC WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of PKA I alpha reg antibody
Western blot of PKA Ialpha reg antibody
Western blot of PKA I alpha reg antibody
Western blot of PKA Ialpha reg antibody

PRKAR1A Antibody LS-C662009
Rabbit Polyclonal to Human PRKAR1A
Human
IHC IHC-P WB
Unconjugated
100µg  $355.00
PRKAR1A was detected in paraffin-embedded sections of rat testis tissues using rabbit anti- PRKAR1A Antigen Affinity purified polyclonal antibody
PRKAR1A was detected in paraffin-embedded sections of human intestinal cancer tissues using rabbit anti- PRKAR1A Antigen Affinity purified polyclonal antibody
PRKAR1A was detected in paraffin-embedded sections of rat testis tissues using rabbit anti- PRKAR1A Antigen Affinity purified polyclonal antibody
PRKAR1A was detected in paraffin-embedded sections of human intestinal cancer tissues using rabbit anti- PRKAR1A Antigen Affinity purified polyclonal antibody

PRKAR1A Antibody (aa1-30) LS-C330604
Rabbit Polyclonal (IgG) to Human PRKAR1A
Human
ELISA IHC WB
Unconjugated
200µl 0.25mg/ml  $530.00

PRKAR1A Antibody (aa1-30, Biotin) LS-C226179
Rabbit Polyclonal (IgG) to Human PRKAR1A
Human
ELISA IHC WB
Biotin Conjugated
200µl  $680.00

PRKAR1A Antibody (aa1-30, FITC) LS-C226181
Rabbit Polyclonal (IgG) to Human PRKAR1A
Human
ELISA IHC WB
FITC Conjugated
200µl  $680.00

PRKAR1A Antibody (aa1-30, AP) LS-C226178
Rabbit Polyclonal (IgG) to Human PRKAR1A
Human
ELISA IHC WB
AP Conjugated
200µl  $680.00

PRKAR1A Antibody (aa1-30, PE) LS-C226185
Rabbit Polyclonal (IgG) to Human PRKAR1A
Human
ELISA IHC WB
PE Conjugated
200µl  $680.00

PRKAR1A Antibody (aa1-30, APC) LS-C226177
Rabbit Polyclonal (IgG) to Human PRKAR1A
Human
ELISA IHC WB
APC Conjugated
200µl  $680.00

PRKAR1A Antibody (aa1-30, Azide-free, HRP) LS-C226183
Rabbit Polyclonal (IgG) to Human PRKAR1A
Human
ELISA IHC WB
HRP Conjugated, Azide-free
200µl  $680.00

PRKAR1A Antibody LS-C751885
Rabbit Polyclonal (IgG) to Human PRKAR1A
Human
ELISA IHC WB
Unconjugated
100µg  $355.00

PRKAR1A Antibody (clone 3546C2a) LS-C184513
Mouse Monoclonal [clone 3546C2a] (IgG1) to Human PRKAR1A
Human
DB WB
Unconjugated
50µg 0.1mg/ml  $325.00

PRKAR1A Antibody (clone 3546C2a) LS-C342551
Mouse Monoclonal [clone 3546C2a] (IgG1) to Human PRKAR1A
Human
DB WB
Unconjugated
100µg 0.1mg/ml  $375.00
Detection of human PRKAR1A by Western blot. Samples: Whole cell lysate (25 ug) from HEK293 cells. Predicted molecular weight: 42 kDa
Western blot analysis of immunized recombinant protein, using anti-PRKAR1A monoclonal antibody.
Detection of human PRKAR1A by Western blot. Samples: Whole cell lysate (25 ug) from HEK293 cells. Predicted molecular weight: 42 kDa
Western blot analysis of immunized recombinant protein, using anti-PRKAR1A monoclonal antibody.

PRKAR1A Antibody (aa1-50) LS-C290340
Rabbit Polyclonal (IgG) to Human PRKAR1A
Human
IP WB
Unconjugated
100µl 1mg/ml  $395.00

PRKAR1A Antibody (aa50-100) LS-C290341
Rabbit Polyclonal (IgG) to Human PRKAR1A
Rabbit, Guinea pig, Human
IP WB
Unconjugated
100µl 1mg/ml  $395.00

PRKAR1A Antibody LS-C746277
Rabbit Polyclonal (IgG) to Human PRKAR1A
Human
IHC-P WB
Unconjugated
50µl  $345.00

PRKAR1A Antibody (aa271-320) LS-C118775
Rabbit Polyclonal (IgG) to Human PRKAR1A
Mouse, Rat, Human
Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Western blot analysis of lysates from HepG2 cells, using KAP0 Antibody. The lane on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from HepG2 cells, using KAP0 Antibody. The lane on the right is blocked with the synthesized peptide.

PRKAR1A Antibody LS-C75190
Mouse Monoclonal (IgG1) to Human PRKAR1A
Human
WB
Unconjugated
50µg 50µl  $385.00

PRKAR1A Antibody LS-C658761
Rabbit Polyclonal to Human PRKAR1A
Mouse, Rat, Human
WB
Unconjugated
100µl  $305.00
Showing 1-25 of 31 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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