PRKAG3 / AMPK Gamma 3

protein kinase, AMP-activated, gamma 3 non-catalytic subunit

AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.

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Products

Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

PRKAG3 / AMPK Gamma 3 (4)

Publications

No (4)

Tag

GST (1)

His (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Mouse (1)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human PRKAG3 / AMPK Gamma 3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88171

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.1 kDa

Price:

20 µg/$215

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Human PRKAG3 / AMPK Gamma 3 Protein (Recombinant GST) (Full Length) - LS-G33920

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

80.7 kDa

Price:

10 µg/$479; 25 µg/$670

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Mouse PRKAG3 / AMPK Gamma 3 Protein (Recombinant His) (aa238-467) - LS-G25706

Source:

E. coli

Tag:

His

Molecular Weight:

29.9 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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PRKAG3 / AMPK Gamma 3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G112459

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.1 kDa

Price:

100 µg/$710

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