PRKAG2 / AMPK Gamma 2

protein kinase, AMP-activated, gamma 2 non-catalytic subunit

AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive.

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Products

Proteins (8)

Type

Over-Expression Lysate (4)

Recombinant (4)

Target

PRKAG2 / AMPK Gamma 2 (8)

Publications

No (8)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (4)

Species

Human (5)

Mouse (1)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human PRKAG2 / AMPK Gamma 2 Protein (Recombinant GST) (Full Length) - LS-G33766

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

63.9 kDa

Price:

10 µg/$479; 25 µg/$670

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PRKAG2 / AMPK Gamma 2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G120356

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58.3 kDa

Price:

100 µg/$710

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Human PRKAG2 / AMPK Gamma 2 Protein (Recombinant 6His, N-terminus) (aa1-328) - LS-G57567

Source:

E. coli

Tag:

6His, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human PRKAG2 / AMPK Gamma 2 Protein (Recombinant GST, N-terminus) (aa191-300) - LS-G62472

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PRKAG2 / AMPK Gamma 2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G84211

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58.3 kDa

Price:

20 µg/$215

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Human PRKAG2 / AMPK Gamma 2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G84212

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

62.9 kDa

Price:

20 µg/$215

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PRKAG2 / AMPK Gamma 2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101400

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

62.9 kDa

Price:

100 µg/$710

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Mouse PRKAG2 / AMPK Gamma 2 Protein (Recombinant His-T7) (aa290-508) - LS-G15270

Source:

E. coli

Tag:

His-T7

Molecular Weight:

29.1 kDa

Price:

10 µg/$284; 50 µg/$460; 100 µg/$735; 200 µg/$917; 1 mg/$2,037; 500 µg/$1,571; 5 mg/$3,207; 2 mg/$2,225

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