PRKACA

protein kinase, cAMP-dependent, catalytic, alpha

Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca2+, leading to reduced amplitude and increased frequency of store overload-induced Ca2+ release (SOICR) characterized by an increased rate of Ca2+ release and propagation velocity of spontaneous Ca2+ waves, despite reduced wave amplitude and resting cytosolic Ca2+. PSMC5/RPT6 activation by phosphorylation stimulates proteasome. Negatively regulates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding. Involved in embryonic development by down-regulating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis. Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation. May also regulate rapid eye movement (REM) sleep in the pedunculopontine tegmental (PPT). Phosphorylates APOBEC3G and AICDA. Isoform 2 phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation.

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Antibodies (20)

ELISA Kits (11)

Proteins (9)

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Cell-Based (1)

Custom (5)

Over-Expression Lysate (4)

Primary (20)

Recombinant (5)

Sandwich (5)

Target

PRKACA (40)

Reactivity

Human (23)

Mouse (11)

Rat (10)

Bat (3)

Bovine (6)

Chimpanzee (6)

Dog (7)

Gibbon (6)

Guinea pig (3)

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Orangutan (3)

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IHC-P (6)

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IF (2)

Peptide-ELISA (5)

Host

rabbit (17)

mouse (1)

goat (2)

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IgG (9)

IgG1 (1)

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monoclonal mc (1)

polyclonal pc (19)

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7H3A4 (1)

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FITC Conjugated (2)

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280-360 aa (1)

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Adherent Cell Cultures (1)

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GST, N-terminus (2)

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Species

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Source

293T Cells (2)

HEK 293 Cells (4)

Wheat Germ Extract (3)

Purification

Purified (1)

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PRKACA Antibody (N-Terminus) LS-B11535

Antibody:

PRKACA Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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PRKACA Antibody (N-Terminus, HRP) LS-C464152

Antibody:

PRKACA Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody

Reactivity:

Xenopus, Zebrafish, Pig, Horse, Bat, Rabbit, Mouse, Dog, Guinea pig, Sheep, Bovine, Rat, Human, Monkey, Gibbon, Orangutan, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

PRKACA Antibody (N-Terminus, Biotin) LS-C464150

Antibody:

PRKACA Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody

Reactivity:

Xenopus, Zebrafish, Pig, Horse, Bat, Rabbit, Mouse, Dog, Guinea pig, Sheep, Bovine, Rat, Human, Monkey, Gibbon, Orangutan, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

PRKACA Antibody (N-Terminus, FITC) LS-C464151

Antibody:

PRKACA Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody

Reactivity:

Xenopus, Zebrafish, Pig, Horse, Bat, Rabbit, Mouse, Dog, Guinea pig, Sheep, Bovine, Rat, Human, Monkey, Gibbon, Orangutan, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

PRKACA Antibody LS-C801521

Antibody:

PRKACA Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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PRKACA Antibody LS-C800477

Antibody:

PRKACA Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

PRKACA Antibody (280-360 aa) LS-C381548

Antibody:

PRKACA Rabbit anti-Human Polyclonal (280-360 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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PRKACA Antibody (clone 7H3A4) LS-C669171

Antibody:

PRKACA Mouse anti-Human Monoclonal (7H3A4) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$459

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PRKACA Antibody (Preservative Free) LS-C815409

Antibody:

PRKACA Rabbit anti-Human Polyclonal (Preservative Free) Antibody

Reactivity:

Human

Applications:

IHC-P, WB

Format:

Unconjugated, Preservative Free

Price:

100 µl/$412

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PRKACA Antibody LS-C822618

Antibody:

PRKACA Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

PRKACA Antibody LS-C801803

Antibody:

PRKACA Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

PRKACA Antibody LS-C769851

Antibody:

PRKACA Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$250; 60 µl/$286; 120 µl/$349; 200 µl/$439

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PRKACA Antibody LS-C502367

Antibody:

PRKACA Goat anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

Select

PRKACA Antibody LS-C502374

Antibody:

PRKACA Goat anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

Select

PRKACA Antibody (phospho-Ser339) LS-C411570

Antibody:

PRKACA Rabbit anti-Human Polyclonal (pSer339) Antibody

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$287; 50 µl/$341; 100 µl/$431; 200 µl/$539

Select

PRKACA Antibody (N-Terminus) LS-C116755

Antibody:

PRKACA Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

PRKACA Antibody (N-Terminus, HRP) LS-C464155

Antibody:

PRKACA Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody

Reactivity:

Xenopus, Zebrafish, Pig, Horse, Rabbit, Dog, Sheep, Bovine, Human, Monkey, Chimpanzee, Gibbon

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

PRKACA Antibody (N-Terminus, Biotin) LS-C464153

Antibody:

PRKACA Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody

Reactivity:

Xenopus, Zebrafish, Pig, Horse, Rabbit, Dog, Sheep, Bovine, Human, Monkey, Chimpanzee, Gibbon

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

PRKACA Antibody (N-Terminus, FITC) LS-C464154

Antibody:

PRKACA Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody

Reactivity:

Xenopus, Zebrafish, Pig, Horse, Rabbit, Dog, Sheep, Bovine, Human, Monkey, Chimpanzee, Gibbon

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

PRKACA Antibody (Preservative Free) LS-C814986

Antibody:

PRKACA Rabbit anti-Human Polyclonal (Preservative Free) Antibody

Reactivity:

Human

Applications:

IHC-P

Format:

Unconjugated, Preservative Free

Price:

100 µl/$412

Select

Human PRKACA Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65161

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.4 kDa

Price:

20 µg/$1,107

Select

Human PRKACA Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65162

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.6 kDa

Price:

20 µg/$1,107

Select

Human PRKACA Protein (Recombinant GST, N-terminus) (aa1-120) - LS-G59716

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human PRKACA Protein (Recombinant GST, N-terminus) (aa252-350) - LS-G59718

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human PRKACA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74972

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

40.4 kDa

Price:

20 µg/$150

Viewing 1-25 of 40 product results

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