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PRG2 / Proteoglycan 2

proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)

PRG2 / Proteoglycan 2 is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Synonyms: PRG2, BMPG, Bone marrow proteoglycan, Bone-marrow proteoglycan, Eosinophil major basic protein, MBP1, Natural killer cell activator, Proteoglycan 2, Proteoglycan 2 preproprotein
Target Sequences: NM_002728 NP_002719.3 P13727

Publications (1)

1
Fibrinogen Is a Specific Trigger for Cytolytic Eosinophil Degranulation. Mackenzie E Coden, Lucas F Loffredo, Matthew T Walker, Brian M Jeong, Kiwon Nam, Bruce S Bochner, Hiam Abdala-Valencia, Sergejs Berdnikovs. Journal of immunology (Baltimore, Md. : 1950). 2020 January;204:438-448. [Full Text Article] [PubMed:31818982]

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ELISA Kits (7)
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PRG2 / Proteoglycan 2 (7)
Human (3)
Mouse (3)
Rat (1)
96-Well Strip Plate (7)
No (7)
Cell Lysates (1)
Plasma (4)
Serum (4)
Tissue Homogenates (3)
PRG2 / Proteoglycan 2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$798
PRG2 / Proteoglycan 2 ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Mouse
54.9 - 40000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$990
PRG2 / Proteoglycan 2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$818
PRG2 / Proteoglycan 2 ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
PRG2 / Proteoglycan 2 ELISA Kit
Select
Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$783
PRG2 / Proteoglycan 2 ELISA Kit
Select
Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$783
PRG2 / Proteoglycan 2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).