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Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
Gene Name: | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 |
Synonyms: | PREX1, KIAA1415, P-REX1 |
Target Sequences: | NM_020820 NP_065871.2 Q8TCU6 |
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