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PRDM9
PR domain containing 9
Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the ability to mono- and dimethylate 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase.
| Gene Name: | PR domain containing 9 |
| Synonyms: | PRDM9, MSBP3, PR domain-containing protein 9, MEISETZ, PFM6, PR domain containing 9, ZNF899, PRMD9 |
| Target Sequences: | NM_020227 NP_064612.2 Q9NQV7 |
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