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PRDM2 / RIZ1
PR domain containing 2, with ZNF domain
This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | PR domain containing 2, with ZNF domain |
| Synonyms: | PRDM2, GATA-3 binding protein G3B, GATA-3-binding protein G3B, HUMHOXY1, KMT8, Lysine N-methyltransferase 8, RIZ2, MTE-binding protein, PR domain-containing protein 2, RIZ, Zinc finger protein RIZ, MTB-ZF, RIZ1 |
| Target Sequences: | NM_012231 NP_036363.2 Q13029 |
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