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PRDM16

PR domain containing 16

Binds DNA and functions as a transcriptional regulator. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions also as a repressor of TGF-beta signaling. Isoform 4 may regulate granulocytes differentiation.

Gene Name: PR domain containing 16
Synonyms: PRDM16, KIAA1675, MDS1/EVI1-like gene 1, MEL1, PFM13, Transcription factor MEL1, PR domain containing 16
Target Sequences: NM_022114

Publications (1)

1
Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis. Qinjie Weng, Jincheng Wang, Jiajia Wang, Danyang He, Zuolin Cheng, Feng Zhang, Ravinder Verma, Lingli Xu, Xinran Dong, Yunfei Liao, Xuelian He, Andrew Potter, Liguo Zhang, Chuntao Zhao, Mei Xin, Qian Zhou, Bruce J Aronow, Perry J Blackshear, Jeremy N Rich, Qiaojun He, Wenhao Zhou, Mario L Suvà, Ronald R Waclaw, S Steven Potter, Guoqiang Yu, Q Richard Lu. Cell stem cell. 2019 May;24:707-723e8. [Full Text Article] [PubMed:30982771] [PMC:PMC6669001] Related Antibodies: LS-B4625.

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Myc-DDK (Flag) (3)
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HEK 293 Cells (2)
PRDM16 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
140.1 kDa
20 µg/$215
PRDM16 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
140.1 kDa
100 µg/$710
PRDM16 Protein - Purified recombinant protein PRDM16 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
140.1 kDa
20 µg/$1,107
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).