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PRDM16

PR domain containing 16

Binds DNA and functions as a transcriptional regulator. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemical energy in the form of heat in response to cold or excess feeding while white adipose tissue (WAT) is specialized in the storage of excess energy and the control of systemic metabolism. Together with CEBPB, regulates the differentiation of myoblastic precursors into brown adipose cells. Functions also as a repressor of TGF-beta signaling. Isoform 4 may regulate granulocytes differentiation.

Gene Name: PR domain containing 16
Synonyms: PRDM16, KIAA1675, MDS1/EVI1-like gene 1, MEL1, PFM13, Transcription factor MEL1, PR domain containing 16
Target Sequences: NM_022114

Publications (1)

1
Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis. Qinjie Weng, Jincheng Wang, Jiajia Wang, Danyang He, Zuolin Cheng, Feng Zhang, Ravinder Verma, Lingli Xu, Xinran Dong, Yunfei Liao, Xuelian He, Andrew Potter, Liguo Zhang, Chuntao Zhao, Mei Xin, Qian Zhou, Bruce J Aronow, Perry J Blackshear, Jeremy N Rich, Qiaojun He, Wenhao Zhou, Mario L Suvà, Ronald R Waclaw, S Steven Potter, Guoqiang Yu, Q Richard Lu. Cell stem cell. 2019 May;24:707-723e8. [Full Text Article] [PubMed:30982771] [PMC:PMC6669001] Related Antibodies: LS-B4625.

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Antibodies (14)
Primary (14)
PRDM16 (14)
Human (14)
Mouse (6)
Rat (1)
Chimpanzee (3)
Dog (3)
Guinea pig (3)
Horse (3)
Monkey (1)
IHC (3)
IHC-P (2)
WB (8)
Flo (1)
ELISA (6)
IF (2)
Peptide-ELISA (2)
rabbit (12)
mouse (1)
goat (1)
Product Group
IHCPlus (1)
IgG (6)
IgG1,k (1)
monoclonal mc (1)
polyclonal pc (13)
1740CT793.52.44 (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
Unconjugated (8)
aa539-588 (4)
aa1264-1276 (1)
aa771-804 (1)
No (13)
Yes (1)
PRDM16 Antibody - Anti-PRDM16 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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PRDM16 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
PRDM16 Antibody - Immunohistochemistry of paraffin-embedded human brain tissue at dilution of 1:100
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PRDM16 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
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PRDM16 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
PRDM16 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
Select
PRDM16 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
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PRDM16 Rabbit anti-Human Polyclonal Antibody
Human
IHC
Unconjugated
100 µg/$393
PRDM16 Antibody - Western blot of lysates from LNCaP cell line, mouse lung tissue lysate (from left to right) with PRDM16 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 35 ug per lane.
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PRDM16 Rabbit anti-Human Polyclonal (aa771-804) Antibody
Mouse, Human
WB
Unconjugated
400 µl/$393
PRDM16 Antibody - All lanes: Anti-PRDM16 Antibody at 1:4000 dilution Lane 1: Jurkat whole cell lysate Lane 2: K562 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size: 140 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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PRDM16 Mouse anti-Human Monoclonal (1740CT793.52.44) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$393
PRDM16 Antibody - PRDM16 / MEL1 antibody flow cytometric analysis of paraformaldehyde fixed HEK293 cells (blue line), permeabilized with 0.5% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (1ug/ml). IgG control: Unimmunized goat IgG (black line) followed by Alexa Fluor 488 secondary antibody.
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PRDM16 Goat anti-Human Polyclonal (aa1264-1276) Antibody
Human, Monkey
Flo, Peptide-ELISA
Unconjugated
100 µg/$503
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PRDM16 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PRDM16 Antibody - PRDM16 antibody Western blot of HepG2 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PRDM16 Rabbit anti-Human Polyclonal (aa539-588) Antibody
Human
WB
Unconjugated
100 µl/$424
PRDM16 Antibody - PRDM16 antibody Western blot of HepG2 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PRDM16 Rabbit anti-Human Polyclonal (aa539-588) (HRP) Antibody
Mouse, Dog, Guinea pig, Horse, Human, Chimpanzee
WB
HRP Conjugated
100 µl/$469
PRDM16 Antibody - PRDM16 antibody Western blot of HepG2 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PRDM16 Rabbit anti-Human Polyclonal (aa539-588) (Biotin) Antibody
Mouse, Dog, Guinea pig, Horse, Human, Chimpanzee
WB
Biotin Conjugated
100 µl/$469
PRDM16 Antibody - PRDM16 antibody Western blot of HepG2 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PRDM16 Rabbit anti-Human Polyclonal (aa539-588) (FITC) Antibody
Mouse, Dog, Guinea pig, Horse, Human, Chimpanzee
WB
FITC Conjugated
100 µl/$469
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).