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Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
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PR / Progesterone Receptor
progesterone receptor
The progesterone receptor, a NR3 Steroid Receptor, is induced in granulosa cells of preovulatory follicles in response to surges in luteinizing hormone. It is essential for ovulation and egg implantation. A decrease in expression of endometrial progesterone receptor results in infertility in women. This receptor mediates the progesterone-induced transcription of proteases including ADAMTS1 and cathepsin L. In breast cancer, progesterone receptors are associated with hormone dependence and prolonged survival. At least two alternatively spliced isoforms have been identified in human: hPR-A (94 kD) is 164 aa shorter than hPR-B (114 kD). In most cell contexts, hPR-B functions as a transcriptional activator of progesterone-responsive genes, whereas hPR-A functions as a transcriptional inhibitor of all steroid hormone receptors. hPR-A and hPR-B have been shown to regulate different sets of genes in human breast cancer cells. Some of these PR-regulated genes are implicated in breast cancer.
Multiplexed assessment of the Southwest Oncology Group-directed Intergroup Breast Cancer Trial S9313 by AQUA shows that both high and low levels of HER2 are associated with poor outcome. Harigopal M, Barlow WE, Tedeschi G, Porter PL, Yeh IT, Haskell C, Livingston R, Hortobagyi GN, Sledge G, Shapiro C, Ingle JN, Rimm DL, Hayes DF. The American journal of pathology. 2010 176:1639-47. (IHC)
[PubMed:20150438]
[PMC:PMC2843456]
2
Evaluation of uterine receptivity after gonadotropin releasing hormone agonist administration as an oocyte maturation trigger: a rodent model. Ezoe K, Murata N, Yabuuchi A, Kobayashi T, Kato K. Scientific reports. 2019 August;9:12519. [Full Text Article]
[PubMed:31467307]
[PMC:PMC6715633]
Related Antibodies: LS-B5236.
3
Immunohistochemistry in Investigative and Toxicologic Pathology. Kyathanahalli S Janardhan, Heather Jensen, Natasha P Clayton, Ronald A Herbert. Toxicologic pathology. 2018 July;46:488-510. [Full Text Article]
[PubMed:29966501]
[PMC:PMC6033701]
Related Antibodies: LS-B5236.
4
Differentiation Patterns of Uterine Carcinomas and Precursor Lesions Induced by Neonatal Estrogen Exposure in Mice. Alisa A Suen, Wendy N Jefferson, Carmen J Williams, Charles E Wood. Toxicologic pathology. 2018 July;46:574-596. [Full Text Article]
[PubMed:29895210]
[PMC:PMC6027618]
Related Antibodies: LS-B5236.
5
Uterine Paramesonephric Cysts in Sprague-Dawley Rats from National Toxicology Program Studies. Daven N Jackson-Humbles, John Curtis Seely, Ronald A Herbert, David E Malarkey, Barry S McIntyre, Paul M Foster, Darlene Dixon. Toxicologic pathology. 2018 Jun;46:421-430. [Full Text Article]
[PubMed:29706125]
[PMC:PMC5999558]
Related Antibodies: LS-B5236.
6
Establishment of two basal-like breast cancer cell lines with extremely low tumorigenicity from Taiwanese premenopausal women. Wen-Ling Kuo, Shir-Hwa Ueng, Chun-Hsing Wu, Li-Yu Lee, Yun-Shien Lee, Ming-Chin Yu, Shin-Cheh Chen, Chi-Chang Yu, Chi-Neu Tsai. Human cell. 2018 Apr;31:154-166. [Full Text Article]
[PubMed:29484537]
[PMC:PMC5852199]
Related Antibodies: LS-C133381.
7
Ovarian stimulation using human chorionic gonadotrophin impairs blastocyst implantation and decidualization by altering ovarian hormone levels and downstream signaling in mice. Ezoe K, Daikoku T, Yabuuchi A, Murata N, Kawano H, Abe T, Okuno T, Kobayashi T, Kato K. Molecular human reproduction. Nov;20:1101-16. [Full Text Article]
[PubMed:25122188]
Related Antibodies: LS-B5236.
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PLEASE NOTE
For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.
The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).