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PPY / Pancreatic Polypeptide
pancreatic polypeptide
PPY / Pancreatic Polypeptide belongs to the NPY family and it encodes a protein that is synthesized as a 95 aa polypeptide precursor in the pancreatic islets of Langerhans. It is cleaved into two peptide products; the active hormone of 36 aa and an icosapeptide of unknown function. The hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain.
| Gene Name: | pancreatic polypeptide |
| Family/Subfamily: | Pancreatic hormone , not assigned-Pancreatic hormone |
| Synonyms: | PPY, Obinepitide, Pancreatic polypeptide Y, Pancreatic prohormone, PP, Pancreatic polypeptide, Pancreatic hormone |
| Target Sequences: | NM_002722 NP_002713.1 P01298 |
Publications (4)
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